Fe3O4@PEG-coated dendrimer modified graphene oxide nanocomposite as a pH-sensitive drug carrier for targeted delivery of doxorubicin

Karimi, Soheyla; Namazi, Hassan

doi:10.1016/j.jallcom.2021.160426

Cited by 73 publications

(20 citation statements)

References 50 publications

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“…Table S1 reports the title, first author, journal, date of publication, and DOI for the seventeen publications [44,[64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79]. Those included were published in sixteen scientific journals ranging from 2008 to 2021.…”

Section: Methodsmentioning

confidence: 99%

“…Of these, 65% were published within the last five years (since 2016), highlighting the advancement of research and research interest in the area of graphene nanomaterials for drug delivery. Table S1 reports the title, first author, journal, date of publication, and DOI for the seventeen publications [43,[63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78]. Those included were published in sixteen scientific journals ranging from 2008 to 2021.…”

Section: Methodsmentioning

confidence: 99%

“…PEG was used in seven publications in combination with other modifications. PEG is a hydrophilic polymer that is used for functionalisation to improve the biocompatibility, water dispersity, solubility, and targeting ability of the nanosystem; in addition, PEG offers high efficacy, non-toxicity, non-immunogenicity, and flexibility [67]. PEG is preferentially used over other polymers as it increases the stability of the nanosystem by reducing the risk of aggregation, opsonisation, and phagocytosis.…”

Section: Nanocarrier Characteristicsmentioning

confidence: 99%

“…The Zn-d 3-rGO nanohybrid offers a high loading efficiency of 99.7%, which may be attributed to the presence of Zn 2+ and the formation of a complex between this positive Zn ion and the -O-H and -O groups on DOX; the complex traps DOX onto the nanocarrier, in addition to hydrogen bonding and π-π stacking of DOX with GO [68]. Karimi and Namazi suggested that the presence of PEG in their GO-TD-Fe 3 O 4 @PEG prevented the diffusion of DOX into the solution, thereby facilitating high loading efficiency in addition to electrostatic interactions, π-π stacking, hydrogen bonding, and hydrophobic interactions [67].…”

Section: Payload Characteristics and Drug Loadingmentioning

confidence: 99%

“…Under acidic conditions, the DOX becomes protonated, changing the -NH 2 to an -NH 3 + group that cannot partake in hydrogen bonding. The hydrogen bonding strength is lower under acidic conditions, thereby increasing the hydrophilicity and solubility of DOX and facilitating its release [36,64,67]. pH-responsive nanocarriers are useful in cancer research as tumour microenvironments have an acidic pH [50].…”

Section: Drug Releasementioning

confidence: 99%

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Drug Release Kinetics of DOX-Loaded Graphene-Based Nanocarriers for Ovarian and Breast Cancer Therapeutics

2021

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Cancer remains one of the leading causes of death worldwide despite extensive efforts at developing curative treatments. Chemotherapy, one of the most common forms of treatment, lacks specificity and can induce collateral damages to healthy surrounding tissues/cells and elicit off-target toxic side effects. The carbon-based nanomaterial graphene, can load aromatic drugs with high efficiency, has good biocompatibility, and can be easily functionalised with targeting ligands, antibodies, and biomolecules to increase the accuracy of targeting specific areas; graphene has therefore been explored as a nanocarrier for classical chemotherapy drugs. In this work, seventeen publications that report the release of doxorubicin (DOX) from 2D graphene-based nanohybrids (graphene oxide and reduced graphene oxide) for the treatment of breast and ovarian cancers have been identified based on a range of inclusion and exclusion criteria. To aid in the clinical translation of proof-of-concept studies, this work identifies the pre-clinical experimental protocols and analyses the release kinetics of these publications. Fifteen of the papers utilised a change in pH as the stimulus for drug release, and two utilised either near infrared (NIR) or ultrasound as the stimulus. The extracted drug release data from these publications were fit to four known kinetic models. It was found that the majority of these data best fit the Weibull kinetic model. The agreement between the kinetic data in previously published literature provides a predictable estimation of DOX release from graphene-based nanocarriers. This study demonstrates the potential conjugation of graphene and DOX in drug delivery applications, and this knowledge can help improve to the design and formulation of future graphene-based nanocarriers. In addition, the use of further experimental testing and the standardisation of experimental protocols will be beneficial for future work. The incorporation of computational modelling prior to pre-clinical testing will also aid in the development of controlled and sustained DOX release systems that offer efficient and efficacious results.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Nanocarrier Characteristicsmentioning

confidence: 99%

Section: Payload Characteristics and Drug Loadingmentioning

confidence: 99%

Section: Drug Releasementioning

confidence: 99%

See 3 more Smart Citations

Drug Release Kinetics of DOX-Loaded Graphene-Based Nanocarriers for Ovarian and Breast Cancer Therapeutics

2021

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Modification of Phase Change Materials for Electric‐Thermal, Photo‐Thermal, and Magnetic‐Thermal Conversions: A Comprehensive Review

Liu,

Qian,

Yang

et al. 2024

Adv Funct Materials

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Phase change materials (PCMs) are widely regarded as one of the most promising thermal energy storage technologies, owing to their outstanding latent heat storage density and controllable thermal storage/release characteristics. However, pure PCM usually has certain limitations in terms of electric‐, photo‐, and magnetic‐thermal conversion. In recent years, research on enhancing these properties through the addition of various fillers has garnered widespread attention. Herein, this paper elaborates on the modification of PCM for electric‐thermal, photo‐thermal, and magnetic‐thermal conversion, including their respective modification strategies, properties, and applications. Therein, a comparative analysis is conducted on the electric‐, photo‐, and magnetic‐thermal conversion efficiency of PCM with different fillers. Further, a summary and analysis are conducted on the addition of some fillers to PCM, which simultaneously improves the conversion performance of the two or three mentioned above, enabling multiple energy conversion. Finally, existing problems, solutions, and future development directions are put forward.

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In‐Silico Nanomedical Exploration of Mefloquine Drug Transport Using Pegylated Graphene Oxide Nanocarrier

Adekoya,

Sadiku

et al. 2024

Advcd Theory and Sims

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This study investigates the in‐silico transport of mefloquine (MQ) by using graphene oxide (GO) and polyethylene glycol (PEG)‐functionalized GO nanocarriers. Density functional theory (DFT) calculations are performed to explore the molecular interactions, electronic properties, thermodynamics, and release kinetics of MQ‐GO and MQ‐GO/PEG complexes across different phases and environmental conditions. Results indicate a strong affinity between MQ and both types of nanocarriers, with the adsorption energies ranging from −59.14 to −143.16 kcal mol−1, particularly in acidic environments. This suggests a potential for targeted drug delivery in acidic tumor micro‐environments. The incorporation of PEG, enhances stability and compatibility across phases, with chi interaction parameters of between 1.36 and 28.47, and the energy of mixture values, ranging from 0.80 to 16.86 kcal mol−1. The release time of MQ from the nanocarriers, varies significantly, depending on the adsorption energy, and ranges from 2.03 × 1030 to 6.98 × 1091 milliseconds across different phases, highlighting the need for further optimization of the drug delivery systems. The findings of this study provide valuable insights into the design and development of novel nanomedicines, based on MQ and GO nanocarriers, with implications for malaria treatments.

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Fe3O4@PEG-coated dendrimer modified graphene oxide nanocomposite as a pH-sensitive drug carrier for targeted delivery of doxorubicin

Cited by 73 publications

References 50 publications

Drug Release Kinetics of DOX-Loaded Graphene-Based Nanocarriers for Ovarian and Breast Cancer Therapeutics

Drug Release Kinetics of DOX-Loaded Graphene-Based Nanocarriers for Ovarian and Breast Cancer Therapeutics

Modification of Phase Change Materials for Electric‐Thermal, Photo‐Thermal, and Magnetic‐Thermal Conversions: A Comprehensive Review

In‐Silico Nanomedical Exploration of Mefloquine Drug Transport Using Pegylated Graphene Oxide Nanocarrier

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