This paper contributes to understanding the effects of research governance on global scientific fields. Using a highly selective comparative analysis of four national governance contexts, we explore how governance arrangements influence the dynamics of global research fields. Our study provides insights into second-level governance effects, moving beyond previous studies focusing primarily on effects on research organizations rooted in national contexts. Rather than study over 100 countries across which our selected CERN-based particle physics global research field operates, we explore conditions for changing the dynamics of global research fields and examine mechanisms through which change may occur. We predict then minimal effects on the epistemic choices and research practices of members of the four local knowledge networks despite variations in governance arrangements, and hence no second-level effects. We assert a research field’s independence from governance depends on its characteristics and the relative importance to researchers of research quality notions. This paper contributes methodologically and has practical implications for policymakers. It suggests governance arrangements affect the epistemic choices and research practices of the local knowledge networks only when certain conditions are met. Policymakers should consider the context and characteristics of a field when designing governance arrangements and policy.