Feasibility and application of an HPLC/UVD to determine dinotefuran and its shorter wavelength metabolites residues in melon with tandem mass confirmation

Rahman, Musfiqur; Park, Jong-Hyouk; El‐Aty, A. M. Abd; Choi, Jeong‐Heui; Yang, Angel; Park, Ki Hun; Mahmud, Nashir Uddin Al; Im, Geon-Jae; Shim, Jae‐Han

doi:10.1016/j.foodchem.2012.08.064

Cited by 37 publications

(21 citation statements)

References 14 publications

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“…The analysis times of the target analytes were 2.58 min (DN), 4.58 min (UF), and 4.89 min (dinotefuran) (Figure ). The total run time was 7 min, which was much shorter than obtained by HPLC–UVD (15 min) or LC–MS/MS (10, 18, and 19 min) .…”

Section: Resultsmentioning

confidence: 88%

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Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Zhang

Duan

et al. 2018

J of Separation Science

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An ultra high-performance liquid chromatography with tandem triple quadrupole mass spectrometry residue method was developed and validated for the quantification and identification of dinotefuran and its main metabolites 1-methyl-3-(tetrahydro-3-furylmethyl) urea and 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine in fruit (watermelon), vegetable (cucumber), cereal (rice), animal-derived foods (milk, egg, and pork), soil, and water. The samples were extracted with acetonitrile containing 15% v/v acetic acid and purified with dispersive solid-phase extraction with octadecylsilane, primary secondary amine, graphitized carbon black, or zirconia-coated silica prior to analysis. The method had an excellent linearity (R ≥ 0.9942, 1-500 μg/L) and satisfactory recoveries (73-102%) at five spiked levels (0.001, 0.01, 0.05, 0.5, and 2 mg/kg) with intra- or interday precision in the range of 0.8-9.5% and 3.0-12.8% for the three compounds in the eight matrices. The limits of quantification were 10 μg/kg for 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine and 1 μg/kg for 1-methyl-3-(tetrahydro-3-furylmethyl) urea and dinotefuran. The applicability of the developed method was demonstrated by determining the occurrence of dinotefuran, 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine, and 1-methyl-3-(tetrahydro-3-furylmethyl) urea in various samples from plants, animal-derived foods, and the environment. From 80 samples, 70 contained dinotefuran (0.8-11.7 μg/kg), among which six also contained 1-methyl-3-(tetrahydro-3-furylmethyl) urea (water and rice, 0.5-0.9 μg/kg).

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Section: Resultsmentioning

confidence: 88%

“…Rahman et al. observed an improvement of extraction efficiency for DN with ACN containing 1% HOAc, and found that acceptable recovery of DN was achieved when 2% HOAc in ACN was chosen as the extraction solvent and for solvent calibration . Rahman et al.…”

Section: Resultsmentioning

confidence: 99%

Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Zhang

Duan

et al. 2018

J of Separation Science

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“…In a previous study of dinotefuran and its metabolites, 22 the low sensitivity and shorter wavelength of HPLC-ultraviolet spectrophotometric analyses, and the quick, easy, cheap, effective, rugged and safe sample preparation method resulted in a failure of dispersive clean-up to eliminate interference from complex matrix components. 22 Hence, to achieve higher sensitivity and selectivity and reduce interference from the matrix effect, we performed LC-MS/MS analyses with an SPE cartridge. In another study, 23 the addition of 2%-4% acetic acid to acetonitrile improved the extraction efficiencies of dinotefuran and its metabolites, although DN recovery was not improved under these conditions compared to that following matrix-matched calibration.…”

Section: Optimisation Of Extraction and Clean-up Proceduresmentioning

confidence: 99%

Determinations of dinotefuran and metabolite levels before and after household coffee processing in coffee beans using solid‐phase extraction coupled with liquid chromatography‐tandem mass spectrometry

et al. 2018

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“…Compared to traditional GC detectors, LC detectors have been employed less frequently with QuEChERS methodology. The main drawbacks are (i) interference problems [32,69,83] and (ii) poor sensitivity resulting in higher detection limits [84].…”

Section: Quick Easy Cheap Effective Rugged and Safe Approach Formentioning

confidence: 99%

“…Detection of an extract purified with QuEChERS d-SPE is quite impossible with traditional LC detectors, owing to vari-ous interferences derived from the matrices [4, 29,30,32,83]. In this regard, it was found that the d-SPE procedure did not provide sufficient cleanup for the determination of carbamates by HPLC-FLD [32].…”

Section: Interference Problemsmentioning

confidence: 99%

Quick, easy, cheap, effective, rugged, and safe sample preparation approach for pesticide residue analysis using traditional detectors in chromatography: A review

Rahman

El‐Aty

Kim

et al. 2016

J of Separation Science

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In pesticide residue analysis, relatively low-sensitivity traditional detectors, such as UV, diode array, electron-capture, flame photometric, and nitrogen-phosphorus detectors, have been used following classical sample preparation (liquid-liquid extraction and open glass column cleanup); however, the extraction method is laborious, time-consuming, and requires large volumes of toxic organic solvents. A quick, easy, cheap, effective, rugged, and safe method was introduced in 2003 and coupled with selective and sensitive mass detectors to overcome the aforementioned drawbacks. Compared to traditional detectors, mass spectrometers are still far more expensive and not available in most modestly equipped laboratories, owing to maintenance and cost-related issues. Even available, traditional detectors are still being used for analysis of residues in agricultural commodities. It is widely known that the quick, easy, cheap, effective, rugged, and safe method is incompatible with conventional detectors owing to matrix complexity and low sensitivity. Therefore, modifications using column/cartridge-based solid-phase extraction instead of dispersive solid-phase extraction for cleanup have been applied in most cases to compensate and enable the adaptation of the extraction method to conventional detectors. In gas chromatography, the matrix enhancement effect of some analytes has been observed, which lowers the limit of detection and, therefore, enables gas chromatography to be compatible with the quick, easy, cheap, effective, rugged, and safe extraction method. For liquid chromatography with a UV detector, a combination of column/cartridge-based solid-phase extraction and dispersive solid-phase extraction was found to reduce the matrix interference and increase the sensitivity. A suitable double-layer column/cartridge-based solid-phase extraction might be the perfect solution, instead of a time-consuming combination of column/cartridge-based solid-phase extraction and dispersive solid-phase extraction. Therefore, replacing dispersive solid-phase extraction with column/cartridge-based solid-phase extraction in the cleanup step can make the quick, easy, cheap, effective, rugged, and safe extraction method compatible with traditional detectors for more sensitive, effective, and green analysis.

show abstract

Feasibility and application of an HPLC/UVD to determine dinotefuran and its shorter wavelength metabolites residues in melon with tandem mass confirmation

Cited by 37 publications

References 14 publications

Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Ultra high performance liquid chromatography with tandem mass spectrometry method for determining dinotefuran and its main metabolites in samples of plants, animal‐derived foods, soil, and water

Determinations of dinotefuran and metabolite levels before and after household coffee processing in coffee beans using solid‐phase extraction coupled with liquid chromatography‐tandem mass spectrometry

Quick, easy, cheap, effective, rugged, and safe sample preparation approach for pesticide residue analysis using traditional detectors in chromatography: A review

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