Feasibility and Roadmap Analysis for Malaria Elimination in China

Zhou, Xiao‐Nong; Xia, Zhigui; Wang, Ru-Bo; Qian, Yingjun; Zhou, Shui-Sen; Utzinger, Jürg; Tanner, Marcel; Kramer, Randall A.; Yang, Weizhong

doi:10.1016/b978-0-12-800869-0.00002-0

Cited by 19 publications

(22 citation statements)

References 63 publications

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“…Poor performance in awareness, attitudes and practices of international labourers from rural areas, low capacity for malaria diagnosis in lower-level administrative healthcare institutions, and infrequency of malaria cases make these challenging characteristics of imported malaria in China [16,20,30]. A critical problem has been observed after a literature review of the challenge to tackle imported malaria in China [30,[34][35][36][37][38][39][40]. It is well known that China's strong healthcare system has wiped out a severe local malaria epidemic through mass intervention and specific strategies, which defines superiority in medical resources of China [41][42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Management of imported malaria cases and healthcare institutions in central China, 2012–2017: application of decision tree analysis

Wang

Cao

et al. 2019

Malar J

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Background: Imported malaria has been an important challenge for China. Fatality rates from malaria increased in China, particularly in Henan Province, primarily due to malpractice and misdiagnoses in healthcare institutions, and the level of imported malaria. This study aims to investigate the relationship between the state of diagnosis and subsequent complications among imported malaria cases at healthcare institutions, based on malaria surveillance data in Henan Province from 2012 to 2017. Methods: A retrospective descriptive analysis was performed using data from the Centre for Disease Control and Prevention, Zhengzhou City, the capital of Henan Province. A decision tree method was exploited to provide valuable insight into the correlation between imported malaria cases and healthcare institutions. Results: From 2012 to 2017, there were 371 imported malaria cases, mostly in males aged between 20 and 50 years, including 319 Plasmodium falciparum cases. First visits of 32.3%, 19.9% and 15.9% malaria cases for treatment were to provincial, municipal and county healthcare institutions, respectively. The time interval between onset and initial diagnosis of 284 cases (76.5%) and the time interval between initial diagnosis and final diagnosis of 197 cases (53.1%) was no more than 72 h. An apparent trend was found that there were notably fewer patients misdiagnosed at first visit to healthcare institutions of a higher administrative level; 12.5% of cases were misdiagnosed in provincial healthcare institutions compared to 98.2% in private clinics, leading to fewer complications at healthcare institutions of higher administrative level due to correct initial diagnosis. In the tree model, the rank of healthcare facilities for initial diagnosis, and number of days between onset and initial diagnosis, made a major contribution to the classification of initial diagnosis, which subsequently became the most significant factor influencing complications developed in the second tree model. The classification accuracy were 82.2 and 74.1%, respectively for the tree models of initial diagnosis and complications developed. Conclusion: Inadequate seeking medical care by imported malaria patients, and insufficient capacity to diagnose malaria by healthcare institutions of lower administrative level were identified as major factors influencing complications of imported malaria cases in Henan Province. The lack of connection between uncommon imported malaria

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Section: Discussionmentioning

confidence: 99%

Management of imported malaria cases and healthcare institutions in central China, 2012–2017: application of decision tree analysis

Wang

Cao

et al. 2019

Malar J

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“…First, because the management of imported malaria involves many departments, effective management mechanisms have not been further improved, and as such, various management measures need to be strengthened in implementation of malaria elimination programmes at all levels [4,5]. Second, the mobile population may lack the awareness, knowledge, and conditions of malaria protection, active consultation and standardized treatment [6]. Without education about the disease, workers risk infection while traveling in highly endemic countries abroad.…”

Section: Prevention Of Malaria Retransmission By Monitoring the Impormentioning

confidence: 99%

Protecting the gains of malaria elimination in China

2020

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“…• Anti-mosquito interventions. During the malaria transmission season, it is encouraged to transform and improve the environment so as to reduce the number of breeding sites and decrease the density of mosquitoes in combination with the patriotic health movement 4 and new rural village development [22]. Measures of IRS and insecticide-treated net (ITN) are required to be applied in malaria foci.…”

Section: Strengthening Vector Controlmentioning

confidence: 99%

“…Among the E-2020 countries, China has made a significant progress on malaria elimination. Both the malaria-endemic territories and indigenous cases have decreased dramatically [4][5][6]. Furthermore, no indigenous cases were reported in China in 2017.…”

Section: Introductionmentioning

confidence: 99%

Malaria Elimination in the People’s Republic of China: Current Progress, Challenges, and Prospects

Zhang¹,

Zhang²,

Feng³

et al. 2018

Towards Malaria Elimination - A Leap Forward

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Background: Anopheles stephensi Listen (1901) is the major malaria vector in the Asia, and recently in some regions of Africa. This species includes three biological forms, namely "type", "intermediate" and "mysorensis" with varying degree of vector competence for malaria parasites. To recognize these siblings of An. stephensi lab strain, we used the morphological features of eggs and several genetic markers i.e. Obp1 (odorant binding protein), mitochondrial oxidases subunit 1 and 2 (COI and COII), nuclear internal transcribed spacer 2 locus (ITS2). Methods: Eggs were collected from individual mosquito (n = 50) and observed for the number of ridges under stereomicroscope. DNA was extracted from female mosquitoes. After amplifying fragments by using different genetic markers (Obp1, COI, COII and ITS2), the PCR products were puri ed and sequenced using Sanger Sequence Technology. Phylogenetic analysis was performed after aligning query sequences against the submitted sequences in GenBank using bioinformatics software. Results: The range of ridges number on each egg oat was 12-13 that corresponds to the mysorensis form. Sequence analysis for COI, COII and ITS2 demonstrated 100%, 99.46% and 99.29% similarity of our species with other Chinese, Indian and Iranian strains of An. stephensi. All the sequences of Obp1 intron I region matched 100% with the previously submitted sequences for An. stephensi sibling C (mysorensis form) from Iran and Afghanistan. Conclusion: The current study elaborately describes the morphological and molecular details (sequence

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Feasibility and Roadmap Analysis for Malaria Elimination in China

Cited by 19 publications

References 63 publications

Management of imported malaria cases and healthcare institutions in central China, 2012–2017: application of decision tree analysis

Management of imported malaria cases and healthcare institutions in central China, 2012–2017: application of decision tree analysis

Protecting the gains of malaria elimination in China

Malaria Elimination in the People’s Republic of China: Current Progress, Challenges, and Prospects

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