Feasibility of Interstitial CT Lymphography Using Optimized Iodized Oil Emulsion in Rats

Abstract

Iodized oil emulsion made with a surfactant mixture (Tween 80 as the main surfactant and TPGS, Kollidon 12 PF, or Span 85 as the cosurfactant) provided sufficient and sustained contrast enhancement on CT of targeted lymph nodes with washout on delayed phase.

Nanoscale iodized oil emulsion: a useful tracer for pretreatment sentinel node detection using CT lymphography in a normal canine gastric model

“…Particles in the size range of 10-200 nm have been known to be more effective for sentinel node detection [28,29]. In our previous report, we demonstrated that iodized oil emulsion made with a surfactant mixture provided sufficient and sustained contrast enhancement on CT of targeted LNs in rat models through the optimization of particle size (approximately 120-130 nm) [18]. Therefore, we applied this agent for SLN detection using endoscopic injection into the canine stomach.…”

“…The details of the particulate nanoscale iodized oil emulsion have been described previously [18]. In brief, polyoxyethylene sorbitan monooleate (Tween 80) and sorbitan trioleate (Span 85) were purchased from Sigma-Aldrich (St. Louis, MO, USA).…”

“…Previously, we reported a newly synthesized radiocontrast material, nanoscale iodized oil emulsion, made with a surfactant mixture that provides sufficient and sustained contrast enhancement of LNs in a rat model [18]. Thus, the purpose of this study was to determine whether CT lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection into the stomach is able to visualize the lymphatics and LNs in a canine model.…”

Direct lymphangiography as treatment option of lymphatic leakage: Indications, outcomes and role in patient's management

“…However, surgical reinterventions are associated with a significantly higher morbidity. Using iodized oil for lymphography as contrast agent, this substance has the potential to induce granulomatous reactions when extravasating [4,5] which may be further assisted by additive conservative measures [6][7][8][9].…”

Interstitial MR Lymphography in Mice: Comparative Study with Gadofluorine 8, Gadofluorine M, and Gadofluorine P

“…[1][2][3][4][5][6][7][8][9][10] Contrast-enhanced sonography can survey only to a limited depth from the detector, and so, it is not suitable for detecting the deep lymphatic system. CT lymphography using water-soluble, nanoparticulate, iodine contrast, oil-in-water emulsion has been reported as a feasible method to detect lymph nodes with high resolution images.…”