Feasibility study for bone health assessment based on photoacoustic imaging method

Tian, Feng; Zhu, Yunhao; Xie, Yejing; Ta, Dean; Yuan, Jie; Cheng, Qian

doi:10.3788/col202018.121704

Cited by 8 publications

(6 citation statements)

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“…Our previous studies successfully isolated PA signals originating from soft tissue, cortical bone, and cancellous bone in the time domain. 45 Using the SoS to calculate the thickness of these three types of media and employing the exponential attenuation law to consider the optical and ultrasonic propagation attenuation of cortical bone and soft tissue, we can compensate the PA signals in further studies to isolate and analyze the pure PA signal corresponding to cancellous bone. 90 – 92 In addition, the diameter of calcaneus bone in the human body is in the range of 2 to 3 cm.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…They proposed a PA physicochemical spectral method for assessing changes in the chemical composition and microstructure of cancellous bone. 44 , 45 Our group has leveraged the MWPA time-frequency spectral analysis method to evaluate both the chemical content (minerals and lipids) and microstructure of bone tissues, based on the distinct optical absorption characteristics and sizes of various chromophores present. 46 , 47 The preceding research in this field demonstrates the successful application of various PAI and spectral analysis methods for osteoporosis diagnosis, making it possible to assess BMD, bone microstructure, and chemical composition in a comprehensive manner.…”

Section: Introductionmentioning

confidence: 99%

“…simulated various aspects of PA in skeletal tissues, including light attenuation and distribution, along with PA signal generation and propagation, based on a three-dimensional model. They proposed a PA physicochemical spectral method for assessing changes in the chemical composition and microstructure of cancellous bone 44 , 45 . Our group has leveraged the MWPA time-frequency spectral analysis method to evaluate both the chemical content (minerals and lipids) and microstructure of bone tissues, based on the distinct optical absorption characteristics and sizes of various chromophores present 46 , 47 .…”

Section: Introductionmentioning

confidence: 99%

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Theoretical and experimental study of attenuation in cancellous bone

Xu,

Xie,

et al. 2024

J. Biomed. Opt.

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. Significance Photoacoustic (PA) technology shows great potential for bone assessment. However, the PA signals in cancellous bone are complex due to its complex composition and porous structure, making such signals challenging to apply directly in bone analysis. Aim We introduce a photoacoustic differential attenuation spectrum (PA-DAS) method to separate the contribution of the acoustic propagation path to the PA signal from that of the source, and theoretically and experimentally investigate the propagation attenuation characteristics of cancellous bone. Approach We modified Biot’s theory by accounting for the high frequency and viscosity. In parallel with the rabbit osteoporosis model, we build an experimental PA-DAS system featuring an eccentric excitation differential detection mechanism. Moreover, we extract a PA-DAS quantization parameter—slope—to quantify the attenuation of high- and low-frequency components. Results The results show that the porosity of cancellous bone can be evaluated by fast longitude wave attenuation at different frequencies and the PA-DAS slope of the osteoporotic group is significantly lower compared with the normal group (** ). Conclusions Findings demonstrate that PA-DAS effectively differentiates osteoporotic bone from healthy bone, facilitating quantitative assessment of bone mineral density, and osteoporosis diagnosis.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Theoretical and experimental study of attenuation in cancellous bone

Xu,

Xie,

et al. 2024

J. Biomed. Opt.

Self Cite

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“…Therefore, PAI combines rich optical contrast with good US spatial resolution in deep tissue [4] , [5] , [6] . PAI has demonstrated the potential in characterizing structural, functional, physiological, and molecular information for medical diagnosis [7] , [8] , [9] , [10] , [11] .…”

Section: Introductionmentioning

confidence: 99%

Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

et al. 2022

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“…Photoacoustic spectroscopy (PAS) has the advantages of high sensitivity and selectivity, 1,2 rapid response, large dynamic detection range, and strong stability which has been widely used for trace gas detection in environmental monitoring, industrial process control, agricultural ecology, climate research, and medical diagnostics. 3,4 In most PAS systems, the acoustic wave was generated in an enclosed chamber and its amplitudes are mainly depend on the incident light power, acoustic sensor sensitivity, and the structure of photoacoustic cell (PA cell). 5 In recent years, three categories of methodologies are generally resorted to enhance the performance of PAS systems.…”

Section: Introductionmentioning

confidence: 99%

Variable diameter T‐shaped cell‐based photoacoustic sensor for trace gas detection

Zha

Zhang

et al. 2022

Micro & Optical Tech Letters

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A compact photoacoustic gas sensor based on variable diameter T-shaped cell for trace gas detection was developed. The acoustic pressure distribution in the variable diameter T-shaped cell and conventional T-shaped photoacoustic cell with the same size were simulated by COMSOL Multiphysics software, which indicated that at the first resonance frequency, the acoustic pressure at the end of the resonance tube of the designed photoacoustic cell is significantly stronger than that at the same position of the conventional T-shaped cell. The performance of the sensor based on the variable diameter T-shaped and conventional one were evaluated by detection of water vapor in atmospheric environment, the comparison shows that the signal-to-noise ratio of the variable diameter T-shaped cell is about 1.6 times greater than that of the conventional one and a detection limit of 6.4 ppmv for water vapor detection was obtained.

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Feasibility study for bone health assessment based on photoacoustic imaging method

Cited by 8 publications

References 0 publications

Theoretical and experimental study of attenuation in cancellous bone

Theoretical and experimental study of attenuation in cancellous bone

Improving photoacoustic imaging in low signal-to-noise ratio by using spatial and polarity coherence

Variable diameter T‐shaped cell‐based photoacoustic sensor for trace gas detection

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