Background The assessment of adherence to warfarin therapy is useful in clinical practice due to its wide variability in dose-response and risks of complications. The aim of this study was to investigate validated instruments used to assess adherence to warfarin therapy. Methods Information was collected from the MEDLINE (PubMed), LILACS, EMBASE, and Cochrane Library databases. Search strategies were applied for each database, with no time limit or language restriction. Inclusion criteria consisted of study participants of ≥ 18 years of age, from both sexes, on chronic anticoagulation with warfarin for any indication and the use of validated instruments to assess adherence to warfarin therapy. Exclusion criteria consisted of duplicate articles, narrative or systematic reviews, and meta-analyses, as well as case reports/series and experimental studies involving animals. Two independent reviewers performed the following steps: evaluation of titles/abstracts, selection of studies after full reading, data extraction, and evaluation of potential bias. Discrepancies were resolved by a third reviewer. Results Overall, 19 articles were selected for this systematic review, including 17 cross-sectional studies, one cohort study, and one quasi-experimental study, published from 2009 to 2019. The validated instruments identified in this review were Morisky Medication Adherence Scale (MMAS), the eight-item Morisky Medication Adherence Scale (MMAS-8), Measurement of Treatment Adherence (MTA), and Brief Medication Questionnaire (BMQ). Only MMAS-8 was tested for reliability, using the internal consistency assessment, with Cronbach's α range 0.56-0.71. Conclusions This review highlighted a gap in knowledge regarding the scarcity of validated instruments to assess adherence to warfarin therapy. Limitations were found in instruments that comprised the assessment of the isolated use of medication and the lack of analysis of other relevant therapeutic aspects. Future studies are needed to develop and validate more comprehensive instruments in an attempt to assess adherence to warfarin therapy.
PROSPERO Registration number CRD42019128324
Keywords Anticoagulants • Medication Adherence • Validation studies • Warfarin
Key points• Adherence to prescribed drugs is currently a major obstacle for outpatients to achieve success in drug therapy. The assessment of adherence behaviors is useful to substantiate intervention strategies that seek to bring about changes in health outcomes as a consequence of drug therapies. • No adapted and validated instruments addressing specificities of warfarin therapy were found in this review. Current instruments to assess adherence to warfarin therapy address the isolated use of the medication with no items covering other relevant aspects of therapy, such as diet and drug interactions. • Further studies are needed to investigate specific scales in order to evaluate adherence to warfarin therapy, employing the assessment of their psychometric properties and applicability in clinical practiceExtended author inf...