Feasibility study of an active wound dressing based on hollow fiber membranes in a porcine wound model

Plettig, Jörn; Johnen, Christa; Bräutigam, Kirsten; Knöspel, Fanny; Wönne, Eva C.; Schubert, Frank; Plöger, Frank; Unger, Juliane K.; Reutzel‐Selke, Anja; Bornemann, Reinhard; Zeilinger, Katrin; Gerlach, Jörg C.

doi:10.1016/j.burns.2014.09.022

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…Novel polymer-based biomaterials in the form of surgical membranes, meshes and dressings are being developed for biomedical use in tissue engineering (Zhang, Zhang, Shi, & Miron, 2013), for the treatment of topical wounds and burns (Okamura et al, 2013;Plettig et al, 2014;Vasile, Pieptu, Dumitriu, Panzariu, & Profire, 2013;Xu et al, 2015), for the repair of hernias (Beale, Hoxworth, Livingston, & Trussler, 2012;Novitsky, 2013) and for the development of haemostatic devices (Granville-Chapman, Jacobs, & Midwinter, 2011;Smith, Laird, Porter, & Bloch, 2013;Gaharwar et al, 2014;Ohta et al, 2014). In the field of wound treatment, membranes based on both natural and synthetic polymers have been reported (Khil, Cha, Kim, Kim, & Bhattarai, 2003;Sionkowska, 2011).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Travan

Scognamiglio

Borgogna

et al. 2016

Carbohydrate Polymers

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Section: Introductionmentioning

confidence: 99%

Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Travan

Scognamiglio

Borgogna

et al. 2016

Carbohydrate Polymers

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“…These novel wound dressings are composed of advanced materials that function to make the wound environment more favourable to the healing process. Examples include a fluorinated methacrylamide chitosan hydrogel that sequesters oxygen and an active wound dressing that mimics an artificial capillary bed by continuously delivering soluble factors 41,42 …”

Section: Acute Cutaneous Wound Healing Modelsmentioning

confidence: 99%

Animal models for the study of acute cutaneous wound healing

Saeed

Martins‐Green

2022

Wound Repair Regeneration

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The process of wound healing is critical to maintaining homeostasis after injury.Although a considerable amount has been learned about this complex process, much remains unknown. Whereas, studies with human volunteers are ideal given the unique nature of the human skin anatomy and immune system, the lack of such clinical access has made animal models prime candidates for use in preclinical studies.This review aims to discuss the strengths and limitations of the commonly used mammalian species in wound healing studies: murine, rabbit and porcine. Thereafter, a survey of models of various acute wounds such as cutaneous, ear, and implant are presented and representative studies that use them are described. This review is intended to acquaint readers with the vast spectrum of models available, each of which has a distinct utility. At the same time, it highlights the importance of utilising clinical samples to complement investigations conducted in animal models. Through this strategy, it is hoped that forthcoming research may be more reflective of the acute wound healing process as it occurs in humans.

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“…4C, D). This configuration was used to model wound repair in vivo (22) and the angiogenesis occurring in cardiac tissue both in vitro and in vivo (6, 7).…”

Section: Hollow Fiber Bioreactor Configurationsmentioning

confidence: 99%

“…This configuration is oriented towards the implantation of bioreactor-generated tissues for therapeutic applications. Pletting et al reported a novel active wound dressing (AWD) based on HF membranes in a porcine wound model (22) (Tab. II).…”

Section: Rectangular Hollow Fiber Bioreactors (Rhfbs)mentioning

confidence: 99%

Hollow Fiber Bioreactor Technology for Tissue Engineering Applications

et al. 2016

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Hollow fiber bioreactors are the focus of scientific research aiming to mimic physiological vascular networks and engineer organs and tissues in vitro. The reason for this lies in the interesting features of this bioreactor type, including excellent mass transport properties. Indeed, hollow fiber bioreactors allow limitations to be overcome in nutrient transport by diffusion, which is often an obstacle to engineer sizable constructs in vitro. This work reviews the existing literature relevant to hollow fiber bioreactors in organ and tissue engineering applications. To this purpose, we first classify the hollow fiber bioreactors into 2 categories: cylindrical and rectangular. For each category, we summarize their main applications both at the tissue and at the organ level, focusing on experimental models and computational studies as predictive tools for designing innovative, dynamic culture systems. Finally, we discuss future perspectives on hollow fiber bioreactors as in vitro models for tissue and organ engineering applications.

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Feasibility study of an active wound dressing based on hollow fiber membranes in a porcine wound model

Cited by 7 publications

References 32 publications

Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Animal models for the study of acute cutaneous wound healing

Hollow Fiber Bioreactor Technology for Tissue Engineering Applications

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