Feasibility study of separation and purification of bile acid derivatives by HPLC on C18 and F5 columns

Ilić, Marko; Pastor, Kristian; Marković, Jelena; Grbović, Ljubica; Јovanović-Šanta, Suzana; Mitrović, Ivana; Rončević, Zorana; Ačanski, Marijana

doi:10.1016/j.steroids.2022.109074

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2023

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“…See DOI: https://doi.org/10.1039/d3gc03095d treating cholesterol gallstones, endometritis, cardiometabolic diseases, and as a tumor biomarker. 9,11,12 Industrial production of DCA involves extraction from animal bile acids-where it co-exists with CA 13 -or by removing the hydroxyl group on the 7th carbon atom of CA via 7α-dehydroxylase, 14 a process which also generates a CA-DCA mixture. Given that the only structural difference between CA and DCA is the hydroxyl group on the 7-position carbon atom, effective isolation of CA and DCA from complex biological extracts or synthetic reaction mixtures has remained highly difficult using conventional separation techniques.…”

Section: Introductionmentioning

confidence: 99%