2020
DOI: 10.26434/chemrxiv.12124206
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Feature-Based Molecular Networking Analysis of the Metabolites Produced by in vitro Solid-State Fermentation Reveals Pathways for the Bioconversion of Epigallocatechin Gallate

Abstract: Dark teas are prepared by a microbial fermentation process. Flavan-3-ol B-ring fission analogues (FBRFAs) are some of the key bioactive constituents that characterise dark teas. The precursors and the synthetic mechanism involved in the formation of FBRFAs are not known. Using a unique solid-state fermentation system with <i>β</i>-cyclodextrin inclusion complexation, as well as targeted chromatographic isolation, spectroscopic identification, and Feature-based Molecular Networking (FBMN) on the Glo… Show more

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