Feature series: animal welfare: current issues and recent developments

Stafford, Kevin J.

doi:10.1080/00480169.2014.963793

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…It is important to test for CDV when suspicious of CAdV-1 infection, as multiple studies have reported co-infection of the two viruses, which can increase the mortality rate [22–24]. A post-vaccinal CDV infection has also been previously reported [25] and could have been a possible differential diagnosis for the neurologic signs in this puppy but this was ruled out by the lack of IHC for CDV in the brain tissues.…”

Section: Discussionmentioning

confidence: 78%

Canine adenovirus type 1 causing neurological signs in a 5-week-old puppy

et al. 2019

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BackgroundInfectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease is rarely reported in the veterinary literature.Case presentationA 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal neurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after presentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on vasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry on brain tissue confirmed CAdV-1 infection.ConclusionsThis report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated dogs that present with neurological signs. Further studies are required to better understand the neurotrophic tendencies of this virus.

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Section: Discussionmentioning

confidence: 78%