Features of anosmia in COVID-19

Klopfenstein, Timothée; Kadiane-Oussou, N’dri Juliette; Toko, Lynda; Royer, P; Lepiller, Quentin; Gendrin, Vincent; Zayet, Souheil

doi:10.1016/j.medmal.2020.04.006

Cited by 390 publications

(488 citation statements)

References 18 publications

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“…We noticed two otorhinolaryngological symptoms: dysgeusia and anosmia, reported by more than half of the confirmed COVID-19 patients. These symptoms have been recently described related to SARS-CoV-2 [3,6,7]. Lechien et al reported gustatory disorders in 89% of their patients (n = 342/417) and olfactory disorders in 86% (n = 357/417) [6], these higher percentages may be explained by a selection bias with outpatients consulted at Otorhinolaryngology department.…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients

Zayet¹,

Klopfenstein²,

Mercier³

et al. 2020

Infection

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Section: Discussionmentioning

confidence: 87%

“…In a recent publication, we showed that anosmia began 4.4 (± 1.9 [1][2][3][4][5][6][7][8]) days after infection onset [7]. The mean duration of anosmia was 8.9 (± 6.3 [1-21]) days and 98% of patients recovered within 28 days [7].…”

Section: Discussionmentioning

confidence: 99%

Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients

Zayet¹,

Klopfenstein²,

Mercier³

et al. 2020

Infection

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“…warrant hospitalization, 7,28,32,33 another 3 involved a mix of both inpatient and outpatient populations, 27,29,31 and a final 3 did not address hospitalization status at all. 15,23,30 Furthermore, studies relied on a wide array of instruments to detect olfactory dysfunction, including verbal interview, nonvalidated questionnaires, validated surveys, and validated objective testing such as the UPSIT.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis

Tong

Wong

Zhu

et al. 2020

Otolaryngol.--head neck surg.

560

514

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Objective To determine the pooled global prevalence of olfactory and gustatory dysfunction in patients with the 2019 novel coronavirus (COVID-19). Data Sources Literature searches of PubMed, Embase, and Scopus were conducted on April 19, 2020, to include articles written in English that reported the prevalence of olfactory or gustatory dysfunction in COVID-19 patients. Review Methods Search strategies developed for each database contained keywords such as anosmia, dysgeusia, and COVID-19. Resulting articles were imported into a systematic review software and underwent screening. Data from articles that met inclusion criteria were extracted and analyzed. Meta-analysis using pooled prevalence estimates in a random-effects model were calculated. Results Ten studies were analyzed for olfactory dysfunction (n = 1627), demonstrating 52.73% (95% CI, 29.64%-75.23%) prevalence among patients with COVID-19. Nine studies were analyzed for gustatory dysfunction (n = 1390), demonstrating 43.93% (95% CI, 20.46%-68.95%) prevalence. Subgroup analyses were conducted for studies evaluating olfactory dysfunction using nonvalidated and validated instruments and demonstrated 36.64% (95% CI, 18.31%-57.24%) and 86.60% (95% CI, 72.95%-95.95%) prevalence, respectively. Conclusions Olfactory and gustatory dysfunction are common symptoms in patients with COVID-19 and may represent early symptoms in the clinical course of infection. Increased awareness of this fact may encourage earlier diagnosis and treatment, as well as heighten vigilance for viral transmission. To our knowledge, this is the first meta-analysis to report on the prevalence of these symptoms in COVID-19 patients.

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“…The included studies consist of a variety of study designs -cross-sectional (n = 22) (12,(16)(17)(18)(19)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41); case-control (n = 3) (42-44); casereport and case series (n = 3) studies (45)(46)(47). Two categories of the MMAT were employed based on the study design to examine the methodological quality of these studies; quantitative non-randomized category for cross-sectional and case-control studies and quantitative descriptive category for case-report and case series ones.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Self-report could be done through different ways: an online questionnaire (12,19,27,30,34,37), non-online questionnaire (18,32,35,39,43,44), online checklist (17), the COVID RADAR Symptom Tracker app (16), visual analogue scale (VAS) (25), archived medical records (40,41), or verbally (45,46). Four studies (28,29,31,33) did not report how to measure, just extracted from medical records. In three studies (26,27,42), the Sni n' Sticks screening test for smelling disorders was used to perform psychophysical olfactory evaluation.…”

Section: Olfactory and Gustatory Dysfunction Measurementmentioning

confidence: 99%

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

Esmaeili

Abdi

Shafiee

et al. 2020

Preprint

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BackgroundEvidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. MethodsIn this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6th May 2020. Afterward, all studies reported the taste and smell dysfunction in the COVID-19 patients were included. The quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). The pooled prevalence of olfactory and gustatory dysfunction was estimated using the random effects meta-analysis method.ResultsAmong 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. ConclusionOlfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.

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Features of anosmia in COVID-19

Cited by 390 publications

References 18 publications

Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients

Contribution of anosmia and dysgeusia for diagnostic of COVID-19 in outpatients

The Prevalence of Olfactory and Gustatory Dysfunction in COVID‐19 Patients: A Systematic Review and Meta‐analysis

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

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