Features of electrical brain activity in patients with multiple sclerosis, taking into account the comorbidity

Abstract

The results of the study of brain electrical activity in patients with multiple sclerosis (MS) in the aspect of comorbidity are shown in the work. EEG-study was conducted by 30 patients with MS in dynamics and 15 persons in the control group. The revealed changes in the EEG in patients with MS indicate the dysfunction of the mid-stem brain structures. In the general sample, 46.7% of patients had signs of a decrease in the ascending activating effects on the cortex from the side of the reticular formation of the brainstem. Signs of lowering the threshold of convulsive readiness and irrigation in the form of the alpha-wave activity of the alpha and beta-1 frequency bands, as well as acutewave-slow wave complexes and outbreaks of multiple (beta-1 and beta-2) -waves were detected. In 90% of patients in the general sample, there was a decrease in resistance to functional loads. It was established that in MS patients with comorbidity there is a significant (p <0.001) increase in the spectral power of brain electrical activity in the temporal leads of the right hemisphere in the ranges of theta and beta 1 frequencies and increasing the power of beta-2 activity in the occipital, parietal and temporal leads of both Hemispheres. In terms of the maximum absolute power in the beta-2 frequency range, the differences between the groups were for the large number of leadings of both hemispheres, which may reflect the specific features of the CNS activity, and be associated with the course of MS against the background of comorbidity, in particular pain syndromes.