Features of miRNA binding with mRNA of candidate genes of breast cancer subtypes

CLUSTERS OF miRNAs BINDING SITES in 3′UTR mRNA OF BREAST CANCER CANDIDATE GENES

“…Recently, there have been many studies on the diagnosis of BC using miRNA (mRNA-inhibitory RNA), which play a key role in the post-transcriptional regulation of genes involved in proliferation, differentiation, angiogenesis, migration, apoptosis and carcinogenesis [2]. More than 600 genes are involved in the development of BC [3] and it seems important to identify which of them may be targets for miRNAs. Earlier, we studied the interactions of miRNAs from miRBase database with BC candidate genes [3][4][5] and it was shown that miRNAs can be strong regulators of the expression of many genes and serve as markers for developing methods for early diagnosis of BC [6].…”

“…More than 600 genes are involved in the development of BC [3] and it seems important to identify which of them may be targets for miRNAs. Earlier, we studied the interactions of miRNAs from miRBase database with BC candidate genes [3][4][5] and it was shown that miRNAs can be strong regulators of the expression of many genes and serve as markers for developing methods for early diagnosis of BC [6]. According to the literary data, miRNAs are predominantly bind in the 3′UTR mRNA [7].…”