Features of specific immunity formation in cattle after vaccination against animals anthrax with vaccine of UA-07 "Antravak" strain

Abstract

Introduction. Anthraxisazoonoticdisease, which has keeps being registered in different areas of the world which signifies the constant threatofthediseaseemergenceandspread. One of the current ways of increasing efficiency of anthrax vaccines is applying advanced technologies, protein engineering[1].However, among its disadvantages is that fact the anthrax antigen is easily destroyed by enzymes proteases [2]. Therefore,modernveterinarysciencefaces urgentproblemsofdevelopingeffectivepreventivemeasuresinanimalsagainstanthrax. ON-timevaccinationwithfullcoverageof all livestock, animal revaccination of all kinds,strict control over the gravesites remnantsofcorpsesafterburning,observanceand enforcementofoperatinginstructionsduring improvingactionsindisadvantagedlocations makesthebasisforanthraxprevention[3-4]. G.L.Skadovskyreceivedtheprimarymaterialinthelaboratoryofhisownmanorlocated in our country and later on professor L. S. TsenkovskyyfromtheKharkivUniversityproduced the first vaccine for the vaccination from it. Thus, the first vaccinations were carriedoutbythelocaldoctorofveterinarymed-icineP.V.Voznesensky(1333sheepownedby Skadovsky G. L. were vaccinated). Having examinedtheimmunesystemof30vaccinated and10unvaccinatedsheeptherewasrecorded:«Onthebasisofforegoing,theCommission made completely sure, that the vaccine pre-paredbyProfessorTsenkovsky,protectsheep