February 2017 at a glance: fibrosis, acute heart failure and neurologic abnormalities

Metra, Marco

doi:10.1002/ejhf.760

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is characterized the production of excessive extracellular matrix (ECM) due to the accumulation of inflammatory cells and activated cardiac fibroblasts (CFS). Many lines of evidence indicate that the progression of heart failure manifested by ventricular diastolic and systolic dysfunction is characterized by a marked cardiac hypertrophic and myocardial fibrotic response [53][54][55][56] and ISO can stimulate adrenaline and promote cardiac inflammation and fibrosis, causing decompensation and left ventricular remodeling featured by cell death and the generation of inflammation [57], contributing to the development of myocardial injury and cardiac remodeling models [58,59].…”

Section: Discussionmentioning

confidence: 99%

Effect of injection of different doses of isoproterenol on the hearts of mice

Pan

Gao

et al. 2022

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Heart failure (HF) is one of the diseases that seriously threaten human health today and its mechanisms are very complex. Our study aims to confirm the optimal dose ISO-induced chronic heart failure mice model for better study of HF-related mechanisms and treatments in the future. Methods C57BL/6 mice were used to establish mice model of chronic heart failure. We injected isoproterenol subcutaneously in a dose gradient of 250 mg/kg, 200 mg/kg, 150 mg/kg, 100 mg/kg and 50 mg/kg. Echocardiography and ELISA were performed to figure out the occurrence of HF. We also supplemented the echocardiographic changes in mice over 30 days. Results Except group S and group E, echocardiographic abnormalities were found in other groups, suggesting a decrease in cardiac function. Except group S, myofibrolysis were found in the hearts of mice in other groups. Brain natriuretic peptide was significantly increased in groups B and D, and C-reactive protein was significantly increased in each group. Conclusion Our research finally found that the HFrEF mice model created by injection at a dose of 100 mg/kg for 7 days was the most suitable and a relatively stable chronic heart failure model could be obtained by placing it for 21 days.

show abstract