Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Song, Jin; Lee, Yoo Mi; Choi, You Jin; Jeong, Su Jin

doi:10.1002/jcla.22113

Cited by 16 publications

(15 citation statements)

References 29 publications

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“…Calprotectin is secreted extracellularly from stimulated neutrophils and the FC levels of healthy children exhibit a downward trend with increasing age and reach the adult level by the age of four 19,20. This finding is consistent with recent FC study in healthy children aged less than 4 years in South Korea 21. The children were divided into six age groups and the median FC values was 135 μg/g in 7–12 months group, 65 μg/g in 13–18 months group, 55 μg/g in 19–24 months group, 40 μg/g in 25–30 months group, 21 μg/g in 31–36 months group, and 12 μg/g in 37–48 months group.…”

Section: Discussionsupporting

confidence: 91%

A Study of Fecal Calprotectin in Obese Children and Adults

Park

Kim

2018

JOMES

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Background Obesity is a complex, medical condition causally contributing to many chronic diseases and a number of efforts have been made to find the associated markers for novel prevention and treatment of obesity. Our study was to evaluate the relationship between gut immune response and obesity and overweight with use of fecal calprotectin (FC) both in adult and children groups. Methods Fecal samples were obtained from 74 subjects: 14 non-obese and overweight children (PN), 13 obese and overweight children (PO), 20 non-obese and overweight adults (AN), and 27 obese and overweight adults (AO). FC was measured using a commercial Legend Max quantitative enzyme-linked immunosorbent assay (BioLegend). Mann-Whitney U -test was used for statistical analysis. Results Median FC concentration was 7.9 μg/g (range, 1.9–28.9 μg/g) for PN, 5.0 μg/g (range, 2.6–29.6 μg/g) for PO, 9.5 μg/g (range, 0.8–28.9 μg/g) for AN, and 10.0 μg/g (range, 1.6–25.6 μg/g) for AO, respectively. In both adults and children age groups, the FC showed no statistically significant difference between AO and AN or PO and PN. However, FC showed statistically significant difference ( P <0.05) between AO and PO while not significant between AN and PN. Conclusion FC level in AO was significantly higher than that in PO, suggestive of different pathophysiologic mechanism between children obesity and adults obesity.

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Section: Discussionsupporting

confidence: 91%

A Study of Fecal Calprotectin in Obese Children and Adults

Park

Kim

2018

JOMES

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“…On contrary, fecal calprotectin was higher during the first year of life as we observed here and as has been reported [6,7,[17][18][19]. It has been suggested that the increased permeability of the gut might increase the influx of inflammatory cells in the gut in babies and thus, have an impact on the higher fecal calprotectin values.…”

Section: Discussionsupporting

confidence: 83%

Concentration of fecal calprotectin in 11,255 children aged 0–18 years

Kolho

Alfthan

2020

Scandinavian Journal of Gastroenterology

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Objectives: Fecal calprotectin is a valued surrogate marker for intestinal inflammation. It has been argued that calprotectin levels are higher in early age than in later life hampering the use of calprotectin in young children. Subjects and methods: To study age-related variation, we used data from our laboratory information system on consecutive, unselected fecal calprotectin measurements from 2014 to 2017 in all children aged 0 to 18 years. From each individual, the first measurement was included and repeated measurements were excluded. Fecal calprotectin was quantitated in the major clinical laboratory in southern Finland, HUSLAB with an ELISA kit from Calpro AS (Calpro/Calprolab, Oslo, Norway). Currently, the assay is performed on two automatic pipetting analysers (Dynex DS2, Chantilly, USA) according to the instructions of the manufacturer. Results: There were altogether 11,255 fecal calprotectin results from as many children. The median level of fecal calprotectin was 51 mg/kg in infants < 1 year of age (95 th percentile 648 mg/kg; n ¼ 239). This was 3-4-fold higher when compared to yearly age groups from 1 to 10 years (total number of children included 5,691). Across yearly age groups from 11 to 18, the median values varied from 11 to 19 mg/kg (total number of included children 5,325). The proportion of samples above the routine cutoff for an elevated concentration >100 mg/kg increased with increasing age. Conclusions: Fecal calprotectin values in children beyond the first year of life are in general low and comparable in children and adolescents.

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“…For adults and children, <50 μg/g of FC in stool has been considered within normal limits ( 9 ). However, FC concentration has age-dependent variation in children, especially those younger than 4 years, and increases in infants ( 10 , 11 ). Normally, a high level of FC was reported in healthy neonates, and the usefulness of this marker remains controversial in the neonatal period ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic Changes of Fecal Calprotectin and Related Clinical Factors in Neonates

et al. 2020

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Objective: Fecal calprotectin (FC) has been widely used for a clinical marker of intestinal inflammation in children and adults. However, the clinical usefulness has not been determined in neonates. The purpose of this study was to investigate the change of FC and associated clinical factors in neonates. Methods and Materials: In total, 146 neonates among 472 admissions to our NICU between 2018 and 2019 were included, and 242 stool samples were collected. FC was measured in the first, second, and third–fourth week after birth, respectively, using commercial ELISA. The clinical characteristics were reviewed from medical records. Statistical analyses were performed to analyze associated factors regarding on changes of fecal calprotectin. Results: A wide range from 5.5 to 6,000 mg/kg of FC was observed in neonates. FCs during neonatal period were not correlated with the gestational age at birth or birth weight. The meconial calprotectin was higher than FCs after 2 weeks of age ( n = 134, 418.06 vs. 243.12 in the second week and 259.58 in the third week after birth). Meconial calprotectin was associated with birth weight and meconium stained amniotic fluid. FC during the neonatal period decreased with postnatal week (−464.93 ± 158.02 at third–fourth week after birth compared with the 1st week, P = 0.004) and breast milk (−337.27 ± 150.51 compared with formula milk, P = 0.026). Conclusion: Fecal calprotectin tended to decrease with postnatal week during the neonatal period, and breast milk could affect more decrease of FC.

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Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Cited by 16 publications

References 29 publications

A Study of Fecal Calprotectin in Obese Children and Adults

A Study of Fecal Calprotectin in Obese Children and Adults

Concentration of fecal calprotectin in 11,255 children aged 0–18 years

Dynamic Changes of Fecal Calprotectin and Related Clinical Factors in Neonates

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