2012
DOI: 10.1371/journal.pone.0044328
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Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation

Abstract: Inflammation has classically been defined histopathologically, especially by the presence of immune cell infiltrates. However, more recent studies suggest a role for "low-grade" inflammation in a variety of disorders ranging from metabolic syndrome to cancer, which is defined by modest elevations in pro-inflammatory gene expression. Consequently, there is a need for cost-effective, non-invasive biomarkers that, ideally, would have the sensitivity to detect low-grade inflammation and have a dynamic range broad … Show more

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Cited by 460 publications
(508 citation statements)
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“…Such microbiota encroachment correlated with reduced mucus thickness. Microbiota composition influences the ability of a microbiota to activate innate immune signaling [22]. Thus, we measured the capacity of feces from control and P-80 fed mice to activate pro-inflammatory cytokines the Lipopolysaccharide (LPS) and flagellin receptors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Such microbiota encroachment correlated with reduced mucus thickness. Microbiota composition influences the ability of a microbiota to activate innate immune signaling [22]. Thus, we measured the capacity of feces from control and P-80 fed mice to activate pro-inflammatory cytokines the Lipopolysaccharide (LPS) and flagellin receptors.…”
Section: Discussionmentioning
confidence: 99%
“…Microbiota composition influences the ability of the intestinal microbiome to activate innate immune signaling [22]. P-80 fed mice showed gross histopathological evidence of chronic intestinal inflammation including epithelial damage and a shortened colon (data not shown).…”
Section: Effects Of P-80 On Colonic Mucosa and Microbiota Localizatiomentioning
confidence: 97%
“…For this instance, we are investigating the use of disease biomarkers as a means of balancing cohorts. However, the number of predictive biomarkers in preclinical models of IBD is limiting, although recent studies have been published looking at fecal biomarkers such as calprotectin and lipocalin (Chassaing et al 2012;Cury et al 2013). …”
Section: Randomizationmentioning
confidence: 99%
“…3a). The level of lipocalin 2 in feces, a biomarker of early-phase intestinal inflammation, 16 was significantly elevated in aged AID G23S and AID ¡/¡ mice relative to age-matched wild-type mice (Fig. 3b).…”
Section: A High-affinity and Poly-reactive W27 Iga Targets A Bacteriamentioning
confidence: 95%