Fecal Microbial Transplantation Shows Efficacy in Children With Refractory Ulcerative Colitis - Early Results of Phase I Clinical Trial

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

“…To date, there has been report of three paediatric patients receiving FMT for treatment of UC and C. difficile infections with UC, by nasogastric (NG) tube or enema. 42,43 All of them demonstrated FMT as a feasible and well-tolerated therapy as it is usually given by duodenal endoscopic lavage during endoscopy or performed as an enema. There were no serious adverse events noted in those children.…”

“…Transplantation of healthy donor stool was repeated daily for at least 5 days. After 43 have initiated the first phase I clinical trial for use of FMT in children with UC. They enrolled eight patients and completed data are available on three subjects who have completed the study.…”

Trasplante de microbiota fecal

“…El 67,7% lograron una respuesta clínica completa medida por el índice de Powell-Tuck, el 24,2% una respuesta clínica parcial y el 8% restante no experimentaron ninguna mejoría. Otros autores obtienen tasas de remisión que rondan el 100% [86][87][88][89] .…”