2020
DOI: 10.1096/fj.201901635rr
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Fecal microbiota as a noninvasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver

Abstract: Iron is an essential trace mineral required for growth, metabolism, and immune response. Dysregulation of iron homeostasis is linked with the development and progression of various diseases. Iron accumulation is associated with inflammatory diseases and cancer, while iron deficiency leads to the growth retardation. Several studies have suggested that iron imbalance results in alteration of gut microbiota, leading to the disruption of microbial diversity, the increase of pathogen abundance, and the induction of… Show more

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Cited by 15 publications
(10 citation statements)
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“…Therefore, to identify a particular group of bacteria, a predesigned machine learning algorithm was used. As reported before, we applied a 5-fold cross-validation together with a random forest algorithm to identify potential bacterial biomarkers with consideration of the lowest error rate plus standard deviation ( 28 30 ). With this hypothesis, 16S rDNA gene sequence data from ND and LCD groups before and after the clinical trial were further analyzed.…”
Section: Resultsmentioning
confidence: 99%
“…Therefore, to identify a particular group of bacteria, a predesigned machine learning algorithm was used. As reported before, we applied a 5-fold cross-validation together with a random forest algorithm to identify potential bacterial biomarkers with consideration of the lowest error rate plus standard deviation ( 28 30 ). With this hypothesis, 16S rDNA gene sequence data from ND and LCD groups before and after the clinical trial were further analyzed.…”
Section: Resultsmentioning
confidence: 99%
“…Studies have reported how iron deficiency/repletion in rats ( 90 ) or genetic modification of iron metabolism in mice ( 91 ) affect the gut microbiota composition and metabolic activity. The fecal microbiota has even been proposed as a non-invasive biomarker for tissue iron accumulation prediction in intestine epithelial cells and liver ( 92 ).…”
Section: Gut Microbiota: Modulation Of Iron Homeostasismentioning
confidence: 99%
“…An iron-rich environment in the gut is conducive to Proteobacteria . Studies in children have shown that excess iron causes inflammation and the growth of pathogenic bacteria [ 34 , 70 ].…”
Section: Gut Microbiota and Iron Deficiencymentioning
confidence: 99%