Fecal Microbiota Transplantation: Is It Safe?

Park, Seon-Young; Seo, Geom Seog

doi:10.5946/ce.2021.072

Cited by 71 publications

(36 citation statements)

References 24 publications

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“…Recent advances in analytical techniques have improved our knowledge regarding the relationship between commensal bacteria and intestinal immunity. Microbiota–control interventions with probiotics [ 206 ] and fecal microbiota transplantation (FMT) may be effective in infectious diseases [ 207 , 208 ], but there have been reports of adverse events, and caution may be required [ 209 ], additionally, the differences in indigenous microbiota among nationalities must also be considered. Since interventional studies in humans are limited, in vitro and animal model studies may be useful for research and development [ 69 , 210 , 211 , 212 ].…”

Section: Approaches To the Study Of The Intestinal Microbiota In Infe...mentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.

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Section: Approaches To the Study Of The Intestinal Microbiota In Infe...mentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…75 Recently, some fatal AEs were reported and the safety of FMT was questioned. [76][77][78] Before FMT, physicians should discuss with their patients or clinical trial participants the risks associated with the procedure. The choice of delivery route needs to be based on the specific clinical situation.…”

Section: Safety Of Fecal Microbiota Transplantationmentioning

confidence: 99%

“…Short-term AEs include abdominal pain, diarrhea, flatulence, transient fever, and procedure-related AEs. 78 A systematic review including 129 studies (4241 patients) from years 2000 to 2020 documented the incidence of FMT-related AEs. The results showed that FMT-related AEs were identified in 19% of FMT procedures.…”

Section: Safety Of Fecal Microbiota Transplantationmentioning

confidence: 99%

Clinical Practice Guidelines for Fecal Microbiota Transplantation in Korea

Gweon

Lee

Kim

et al. 2022

J Neurogastroenterol Motil

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Fecal microbiota transplantation (FMT) is a highly efficacious and safe modality for the treatment of recurrent or refractory Clostridioides difficile infection (CDI), with overall success rates of 90%. Thus, FMT has been widely used for 10 years. The incidence and clinical characteristics of CDI, the main indication for FMT, differ between countries. To date, several guidelines have been published. However, most of them were published in Western countries and therefore cannot represent the Korean national healthcare systems. One of the barriers to performing FMT is a lack of national guidelines. Accordingly, multidisciplinary experts in this field have developed practical guidelines for FMT. The purpose of these guidelines is to aid physicians performing FMT, which can be adapted to treat CDI and other conditions.

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“…FMT may be utilized as a rescue therapy for refractory inflammatory bowel disease in the treatment of IBD. FMT alone is relatively safe and can have short-term effects in young patients with active inflammatory bowel disease (IBD) (29), although adverse events related with FMT and associated safety concerns have lately raised concerns (30). Additionally, FMT can help infants with allergic colitis by reestablishing their gut microbiota (31).…”

Section: Gut Microbiota and Inflammatory Bowel Dis-easementioning

confidence: 99%

A Narrative Review of the Gut Microbiota and Its Association with Diseases

Nashin

2022

Sci Insig

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The gut microbiota is vast and diverse, and it is inextricably linked to and interacts with the host. Numerous diseases are associated with the gut microbiota of their occurrence, progression, and prognosis. The gut microbiota has an effect on the occurrence and progression of metabolic diseases through regulating the metabolism of carbohydrates, lipids, and amino acids. Disruptions in the intestinal flora can also contribute to inflammatory bowel disease and certain types of intestinal cancer. Additionally, illnesses of the neuropsychiatric, cardiovascular, and urinary systems, among others, are all associated with the gut microbiota. It is vital to understand the link between gut microbiota and disease in order to prevent, cure, and maintain good health.

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Fecal Microbiota Transplantation: Is It Safe?

Cited by 71 publications

References 24 publications

Role of Microbiota in Viral Infections and Pathological Progression

Role of Microbiota in Viral Infections and Pathological Progression

Clinical Practice Guidelines for Fecal Microbiota Transplantation in Korea

A Narrative Review of the Gut Microbiota and Its Association with Diseases

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