Fecundity, natality, and weight as a function of prenatal alcohol consumption and age of the mother

Phillips, David S.; Stainbrook, Gene L.

doi:10.3758/bf03326696

Psychobiology

1978

DOI: 10.3758/bf03326696

|View full text |Cite

Fecundity, natality, and weight as a function of prenatal alcohol consumption and age of the mother

David S. Phillips

Gene L. Stainbrook

Abstract: The purpose of this study was to investigate the possible interaction between prenatal exposure to alcohol and the age of the mother upon offspring. Two groups of female rats, one who drank only water and one who drank only wine, were mated four times. The fecundity, natality, and weights of the pups were examined. It was concluded that in the rat moderate amounts of alcohol do not affect fecundity but that natality is affected. Birth weight of the pups is also affected by maternal alcohol consumption but not … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1980

1987

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The role of maternal alcohol damage on ethanol teratogenicity in the rat

Sanchis¹,

Sancho‐Tello²,

Chirivella

et al. 1987

Teratology

View full text Add to dashboard Cite

To study the severity and degree of in utero alcohol effects in relation to the rate of maternal alcohol damage, multiparous 1-year alcohol-fed rats were used, with an appropriate pair-fed control group. During pregnancy, alcoholic dams showed relatively high acetaldehyde levels (41 +/- 19 mumol/l) and blood alcohol levels of 22.8 +/- 14 mmol/l. They also showed marked histological alterations in liver as well as high serum aspartate-aminotransferase, alanine-aminotransferase, alkaline phosphatase, glutamate dehydrogenase, and gamma-glutamyltransferase activities. The increase in serum enzyme levels did not correlate with an increase in hepatic enzyme levels since only glutamate dehydrogenase was enhanced in liver after 1 year of alcohol intake. In addition, except for an increase in low Km aldehyde dehydrogenase activity, there were no changes in liver alcohol metabolizing enzymes in chronic alcohol vs. pair-fed females. Alcoholic rats showed a high incidence of damage in their progeny (resorptions, immature fetuses, decrease in fetal weight, etc.), and rats with the highest serum levels of the above enzymes (especially glutamate dehydrogenase and gamma-glutamyl transferase) had severely affected progeny. Rats with minimal histological liver damage, in contrast, did not show resorptions. Thus, the results presented suggest that the stage of maternal alcohol illness, as indicated mainly by the extent of liver damage, plays an important role in the frequency and severity of in utero alcohol effects in the rat.

show abstract

The role of maternal alcohol damage on ethanol teratogenicity in the rat

Sanchis¹,

Sancho‐Tello²,

Chirivella

et al. 1987

Teratology

View full text Add to dashboard Cite

show abstract

Effects of ethanol consumption on maternal behavior in the female rat☆

Mathews

Jamison

1982

Physiology & Behavior

View full text Add to dashboard Cite

Teratogenic Effects of Alcohol in Humans and Laboratory Animals

Streissguth

Landesman-Dwyer

Martin

et al. 1980

Science

607

View full text Add to dashboard Cite

The teratogenicity of alcohol has been demonstrated in humans through clinical studies, behavioral studies, and epidemiologic studies, and in animals through controlled laboratory experiments. In humans exposed to alcohol during gestation the effects can range from fetal alcohol syndrome in some offspring of chronic alcoholic women to reduced average birth weight in offspring of women reporting an average consumption of two to three drinks or more per day. The behavioral effects of such exposure may range from mental retardation in children with fetal alcohol syndrome to milder developmental and behavioral effects in infants born to social drinkers. In animals, exposure to alcohol in utero may result in death, malformation, and growth deficiency as well as behavioral and developmental abnormalities. The mechanisms of impairment and related risk factors are yet to be elucidated.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Fecundity, natality, and weight as a function of prenatal alcohol consumption and age of the mother

Cited by 3 publications

References 12 publications

The role of maternal alcohol damage on ethanol teratogenicity in the rat

The role of maternal alcohol damage on ethanol teratogenicity in the rat

Effects of ethanol consumption on maternal behavior in the female rat☆

Teratogenic Effects of Alcohol in Humans and Laboratory Animals

Contact Info

Product

Resources

About