Feed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins☆

Renaville, Robert; Eenaeme, Christian Van; Breier, Bernhard H.; Vleurick, Lieve; Bertozzi, Carlo; Gengler, Nicolas; Hornick, Jean-Luc; Parmentier, Isabelle; Istasse, Louis; Haezebroeck, Valérie; Massart, Serge; Portetelle, Daniel

doi:10.1016/s0739-7240(99)00076-4

Cited by 47 publications

(22 citation statements)

References 25 publications

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“…In this experiment, restricted feeding decreased the level of plasma IGF-1, which recovered after refeeding to ad libitum levels for 2 days. This is in broad agreement with previous studies in which the level of IGF-1 was found to be reduced during a restriction period, but following refeeding to ad libitum levels increased to the point in which its level reached the same as the control group (Renaville et al, 2000;Therkildsen et al, 2004). Whang et al (2003) reported that the pigs fed the 9% CP diet had a lower level of plasma IGF-1 than pigs fed the 18% CP diet during the depletion phase, whereas there was no effect of compensatory growth on plasma IGF-1 level during re-alimentation period.…”

Section: Discussionsupporting

confidence: 93%

Effect of compensatory growth on performance, carcass composition and plasma IGF-1 in grower finisher pigs

Chaosap

Parr

Wiseman

2011

Animal

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A total of 48 female pigs (Large White 3 Landrace 3 Duroc cross) were used to determine whether a compensatory feed regime influenced performance, carcass composition and the level of plasma IGF-1. Pigs of initial age 73 days were fed a commercial diet at 0.70 of ad libitum (R) for 40 days followed by a return to ad libitum feeding for a further 42 days. The control group was fed ad libitum (A) throughout. Groups of animals on R and A feed regimes were slaughtered at the end of restriction period (SL1), 2 days after refeeding ad libitum (SL2) to establish the more immediate effects of refeeding on IGF levels, and after 42 days refeeding (SL3; n 5 8 for each group). As expected, during the restriction period, average daily live weight gain in all the slaughter groups of R pigs was significantly lower than A pigs ( P , 0.01); there was no significant difference in feed conversion ratios. In the re-alimentation period of SL3, R pigs grew 12.9% faster ( P 5 0.033), indicating compensatory growth. At SL1, there was a trend for carcass weight ( P 5 0.108) of A pigs to be higher than R pigs, but at SL2 live weight and carcass weight of A pigs were significantly heavier than R pigs ( P , 0.05), but not at SL3. For killing-out percentage, there was no difference in SL1. After refeeding for 2 days (SL2) and 42 days (SL3), R pigs had significantly lower killing-out percentage than A pigs ( P , 0.05). As a proportion of live weight, R pigs had smaller heart, kidney and liver ( P , 0.05) than A pigs at SL1. At SL2, only the kidney was smaller in the restricted group ( P , 0.05) and there were no significant differences in SL3. As a proportion of carcass weight, Longissimus dorsi was heavier in the R pigs at SL1 ( P 5 0.108) and SL2 ( P , 0.05), but not at SL3. At SL1, there was a trend for intramuscular fat of A pigs to be higher than R pigs. The plasma IGF-1 level was lower in R pigs than A pigs ( P 5 0.010) at SL1, and slightly lower at SL2 ( P 5 0.110), with no significant differences at SL3. Dietary restriction period influenced plasma IGF-1 levels, which returned to the ad libitum group levels when animals were refed, as did live weight and carcass weight. It appears that the internal organs and possibly fat, but not muscles, underwent a compensatory response when animals were refed.

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Section: Discussionsupporting

confidence: 93%

Effect of compensatory growth on performance, carcass composition and plasma IGF-1 in grower finisher pigs

Chaosap

Parr

Wiseman

2011

Animal

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“…In the current experiment, IGF-I concentrations at day 150 were positively related to energy intake, as other studies reported (Elsasser et al, 1989;Renaville et al, 2000). At slaughter, IGF-I did not differ among management strategies presumably because all the groups had similar concentrate intake and, therefore, energy intakes.…”

Section: Discussionsupporting

confidence: 72%

Effects of pre-weaning concentrate feeding on calf performance, carcass and meat quality of autumn-born bull calves weaned at 90 or 150 days of age

Alibés

Mata

Ripoll

et al. 2008

Animal

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A study was conducted to evaluate the effect of pre-weaning concentrate feeding in early-weaned (EW, day 90) or traditionally weaned (TW, day 150) autumn-born beef calves on growth, feed intake and feed efficiency, and carcass and meat quality. Twenty-eight male calves were either EW or TW, and offered a starter concentrate (S) or no additional feed (NS) during the pre-weaning period. Therefore, four management strategies were tested: EWS, EWNS, TWS and TWNS. Growth patterns were affected by management strategy. From day 90 to 150, TWNS calves presented a substantially lower average daily gain (ADG) than their counterparts, which had similar performance. During the finishing phase (from day 150 to slaughter at 450 kg live weight), EWS calves had the lowest ADG. Daily feed intake or efficiency in the finishing phase was unaffected by previous management. Serum IGF-I concentrations at day 90 and slaughter did not differ with management strategy, but early weaning and pre-weaning concentrate feeding increased IGF-I concentrations at day 150. Circulating leptin concentrations were unaffected by age at weaning and pre-weaning concentrate feeding, except for leptin concentrations at slaughter, which were higher in S calves than in NS calves. Total concentrate intake from birth to slaughter and the concomitant feed costs were higher for EWS and EWNS calves than for TWNS and TWS ones. However, cow feed costs were lower for cows whose calves had been early weaned. Concerning carcass quality, early weaning improved dressing percentage and increased fatness score, and particularly TWNS calves presented a poorer conformation. Meat quality was not affected by management strategy. Considering the economic performance, TWS, EWNS and EWS strategies yielded a similar economic margin, whereas TWNS would be the least advisable strategy when calves are fattened in the farm until slaughter.

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“…Simultaneously, the IGF-I plasma concentration dropped (Gross et al 2011a,b). These results are in agreement with Renaville et al (2000), who observed a decrease in plasma concentrations of IGF-I and IGFBP-3 during feed restriction. This major decrease in IGFBP-3 during the NEB at the onset of lactation might be an attempt to maximise the availability of remaining IGF-I to the tissues (Breier 1999).…”

Section: Discussionsupporting

confidence: 93%

O-serogroups, virulence genes of pathogenic Escherichia coli and Pulsed-field gel electrophoresis (PFGE) patterns of O149 isolates from diarrhoeic piglets in Korea

Byun¹,

Jung²,

Kim³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:Control of metabolic pathways is a major task of the somatotropic axis and its constituents. Insulinlike growth-factor binding proteins (IGFBPs) bind IGF-I and -II and act as carriers and regulators of their activities in blood, body fluids and tissues. Over two periods of physiological adaptation, this study investigated the binding pattern of IGF-I to IGFBPs in the plasma of 50 multiparous Holstein dairy cows and identified relationships with the hepatic mRNA abundance of IGFBPs and plasma IGF-I during the lactational negative energy balance (NEB) and during a deliberately induced NEB by feed restriction. Period 1 lasted from week 3 antepartum (a.p.) to week 12 postpartum (p.p.) and period 2, the period of feed restriction, started at around 100 DIM and lasted for three weeks with a control (C) and a restricted group (R). Blood samples and liver biopsies were collected in week 3 a.p., and in weeks 1 and 4 p.p. of period 1 and in weeks 0 and 3 of period 2. For column chromatography of IGFBPs, plasma samples of all animals were pooled by group and time points of sampling. Plasma IGF-I dropped from week 3 a.p. to week 1 p.p. and thereafter increased until week 0 (period 2) and did not change up to week 3 of period 2. The binding of IGF-I to plasma IGFBP-1 and -2 increased in period 1 from week 3 a.p. to week 4 p.p., while at the same time it decreased for IGFBP-3. During period 2, the binding of IGF-I to plasma IGFBP-1 and -2 decreased for both groups, but less for R cows. In C cows, the IGF-I binding to IGFBP-3 in plasma increased from week 0 to week 3 of period 2, whereas R cows showed a slight decrease. In period 1, hepatic mRNA abundance of IGFBP-3 followed the plasma IGFBP-3 binding in contrast to the mRNA abundances of IGFBP-1 and -2. The latter increased from week 3 a.p. to week 1 p.p. and decreased afterwards whereas IGF-I binding to IGFBP-1 and -2 increased. In week 3 of period 2, the binding of IGF-I to IGFBP-1 and -2 and their hepatic mRNA abundance were higher in R cows compared to C cows. Hepatic mRNA abundance of IGF-I was consistently positively correlated with plasma IGF-I, especially pronounced during the NEBs in week 1 p.p. (period 1) and in week 3 (period 2) in R cows. While no distinct relation between mRNA abundance of IGFBP-1 and plasma IGF-I was evident, the mRNA abundance of IGFBP-2 was inversely related to plasma IGF-I over all experimental time points independent of treatment. The mRNA abundance of IGFBP-3 was particularly correlated with plasma IGF-I during the 2 experimental stages of a NEB. Obviously IGFBP-3, but not IGFBP-1 and -2, binding in plasma closely followed the respective pattern of hepatic mRNA abundance during the entire experimental period. The fact that changes in the different plasma IGFBPs during altering metabolic stages in different stages of lactation do not always strictly follow their mRNA abundance in liver suggests tissues other than the liver flexibly contributing to the IGFBP pool in plasma as well as a partially post-transcriptional regulation of IGF...

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Feed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins☆

Cited by 47 publications

References 25 publications

Effect of compensatory growth on performance, carcass composition and plasma IGF-1 in grower finisher pigs

Effect of compensatory growth on performance, carcass composition and plasma IGF-1 in grower finisher pigs

Effects of pre-weaning concentrate feeding on calf performance, carcass and meat quality of autumn-born bull calves weaned at 90 or 150 days of age

O-serogroups, virulence genes of pathogenic Escherichia coli and Pulsed-field gel electrophoresis (PFGE) patterns of O149 isolates from diarrhoeic piglets in Korea

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