Feedback systems in multi-dose dry powder inhalers

Abstract

Dry powder inhalers (DPIs) are a large, highly diverse group of inhalation devices. DPIs differentiate the process of measuring the dose of the drug and preparing the inhaler for use, but also the way of transmitting and the scope of feedback on the inhalation process that the user receives. The functioning of simple and technologically advanced systems of feedback on the inhalation process in the most commonly used multi-dose DPIs is discussed. All these DPIs have a dose counter. Only three DPIs -Novolizer ® , Genuair ® and NEXThaler ® provide feedback to the patient in the form of auditory and visual signals confirming the correctness of the inhalation performed. This is important for the correct use of the inhaler, and thus for obtaining the expected therapeutic effects.

Postrzeganie inhalatorów suchego proszku przez chorych na astmę

“…Wystarczą bowiem jedynie trzy kroki, podczas gdy w przypadku większości DPI istnieje konieczność wykonania kolejnych 4-11 czynności (tab. 5) [33][34][35]. Jest to zatem jeden z najłatwiejszych w obsłudze inhalatorów, a co za tym idzie -o mniejszym ryzyku popełnienia błędu.…”

BDP/FF NEXThaler to Improve Asthma Control Status in the Real World: The NEWTON Study

“…The characteristics of these inhalers, such as the method of powder aerosolization, the minimum and optimum inspiratory flow, the characteristics of the aerosol cloud formed, the method of use, and feedback on the inhalation procedure, play an important role in determining drug delivery and distribution, thus influencing, together with the chosen drug and patient characteristics, the overall effectiveness of the pharmacological treatment. 15 Innovative Features for Extrafine BDP/FF Delivery NEXThaler ® is a dry-powder inhaler (DPI) with extrafine BDP/FF that presents several unique, original features and feedback systems that facilitate patient control of the entire inhalation process.…”

“…The characteristics of these inhalers, such as the method of powder aerosolization, the minimum and optimum inspiratory flow, the characteristics of the aerosol cloud formed, the method of use, and feedback on the inhalation procedure, play an important role in determining drug delivery and distribution, thus influencing, together with the chosen drug and patient characteristics, the overall effectiveness of the pharmacological treatment. 15 …”

“…The main innovative technical solutions presented by this DPI are: 12 , 15 , 16 The breath-actuated mechanism (BAM) system delays drug delivery until the patient’s inspiratory flow rate is adequate (>35 L/min) to detach drug particles from the lactose carrier. This reduces the emission of large particles (>5 μm), increases the available therapeutic fine particle fraction and favors the deposition of the drug mainly in the lower respiratory tract; The inhalation flow-independent performance allows the delivery of a consistent drug dose during inspiration, regardless of inspiratory flow rate (range, 35–90 L/min); A triple feedback system ensures correct dosage intake.…”