A case of severe 'Haemorrhagic enteritis' was reported in a striped hyena (Hyaena hyaena) at Nandankanan Zoological Park, Odisha, India. The clinical signs, haematological parameters, serum biochemistry showed similarity to a viral infection like 'Canine Parvovirus infection (CPV)'. The hyena was under regular vaccination against CPV using multivalent vaccine meant for domestic dogs. Though the etiological agent behind such acute Haemorrhagic enteritis and leukopaenia could not be isolated with the available laboratory facilities, the striped hyena was successfully treated due to early detection of sickness, prompt and aggressive treatment.