Fellow Eye in Unilateral Primary Congenital Glaucoma

Abstract

AimThis is a report of the incidence of bilateral cases in a cohort of primary congenital glaucoma (PCG) cases and a study of the biometric characteristics of the fellow normal eyes in unilateral cases.Materials and methodsThe charts of 134 PCG children were reviewed, of which 78 cases (58.2%) were found to have bilateral disease. The remaining 56 patients (41.8%) with unilateral disease had their fellow normal eyes compared with an age-matched cohort of ophthalmologically free children.ResultsThere were no differences between the normal fellow eyes of PCG cases and the control eyes in the corneal diameter and central corneal thickness (CCT), whereas the normal fellow eyes of PCG cases had higher intraocular pressure (IOP) and cup/disc (C/D) ratios.ConclusionThe fellow eyes of apparently unilateral PCG cases are not typically normal anatomically like other children unaffected by PCG.Clinical significanceA very high index of suspicion has to be kept for PCG cases that present apparently unilaterally, and meticulous prolonged follow-up is mandatory.How to cite this articleBayoumi NHL. Fellow Eye in Unilateral Primary Congenital Glaucoma. J Curr Glaucoma Pract 2017;11(1):28-30.

Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma: An in vivo high-frequency ultrasound biomicroscopy-based study

“…The current study reports a bilateral PCG incidence of about 72%, consistent with rates in the literature: 60%-99.3% [44]. This higher incidence of bilaterality in other reports may be related to disease severity or underlying genetic abnormality in different ethnic groups.…”

“…Thirdly, with regards to measurement of the largest cross-sectional area of Schlemm's canal, it is possible that this varies from quadrant to quadrant with natural variation at different anatomic locations with the largest cross-sectional area not comprehensively reflecting the anatomy of the whole eye, and the inability to identify SC in the superior quadrant alone could be due to imaging technique for those enlarged PCG eyes and not a consistent anatomical finding. Fourthly, PCG is a genetic disorder and it is likely that the "unaffected" eye is not truly normal [44]. Further studies should address the differences of anterior chamber angle structures between unaffected eyes of PCG patients and normal age-matched eyes.…”

Childhood glaucoma registry in Germany: initial database, clinical care and research (pilot study)

“…Bilateral disease was present in our study in 82% patients with PCG and was higher than the incidence of bilateral PCG (58%), reported by Bayoumi [37]. We observed unilateral disease more frequent in patients with SCG than in PCG, as previously reported [1,20,38].…”