Female lower urinary tract microbiota do not associate with IC/PBS symptoms: a case-controlled study

Bresler, Larissa; Price, Travis K.; Hilt, Evann E.; Joyce, Cara; Fitzgerald, Colleen M.; Wolfe, Alan J.

doi:10.1007/s00192-019-03942-9

Cited by 40 publications

(53 citation statements)

References 19 publications

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“…The decreased number of genera in the post-menopausal group is similar to the decrease seen with aging in the gut microbiome. 16 Two studies 17,18 were identified looking at the urinary microbiome in patients with IC/BPS compared to controls. Meriwether et al 17 analysed vaginal and urinary samples from 23 IC/BPS patients and 18 non-IC/ BPS patients.…”

Section: Resultsmentioning

confidence: 99%

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome

2020

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Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections carry significant burden for those affected. As women enter the menopause, other factors may influence how these conditions manifest. The urinary microbiome has shown that the urine contains extensive numbers of bacteria. There is some evidence to suggest that it is altered depending on the menopausal state of the individual. It is possible that this alteration may go on to influence how the disease course of interstitial cystitis/bladder pain syndrome and recurrent urinary tract infections runs in the post-menopausal group. The review will explore these two conditions and the potential role of the urinary microbiome.

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Section: Resultsmentioning

confidence: 99%

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome

2020

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“…Furthermore, there are many species of Lactobacillus and some may contribute to a healthy or disease bladder. On the other hand, another study that collected urinary samples from 21 IC patients and 20 matched controls found no significant differences in urinary microbiota [37]. The conflicting conclusions between these two recent studies highlight controversy surrounding this fairly new field and the need for a more comprehensive longitudinal study.…”

Section: Microbiome Studies In Urological Diseasesmentioning

confidence: 96%

Biomarker discovery and beyond for diagnosis of bladder diseases

Jung

Kim

2020

Bladder

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Molecular biosignatures of altered cellular landscapes and functions have been casually linked with pathological conditions, which imply the promise of biomarkers specific to bladder diseases, such as bladder cancer and other dysfunctions. Urinary biomarkers are particularly attractive due to costs, time, and the minimal and noninvasive efforts acquiring urine. The evolution of omics platforms and bioinformatics for analyzing the genome, epigenome, transcriptome, proteome, lipidome, metabolome, etc., have enabled us to develop more sensitive and disease-specific biomarkers. These discoveries broaden our understanding of the complex biology and pathophysiology of bladder diseases, which can ultimately be translated into the clinical setting. In this short review, we will discuss current efforts on identification of promising urinary biomarkers of bladder diseases and their roles in diagnosis and monitoring. With these considerations, we also aim to provide a prospective view of how we can further utilize these bladder biomarkers in developing ideal and smart medical devices that would be applied in the clinic.

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“…In women, a single, small study of catheterized urine samples revealed decreased bacterial diversity, with reduced Lactobacillus levels and increased proinflammatory cytokines in IC/BPS compared with controls [22•]. Three studies examining voided urine samples in women with IC/BPS were unable to identify differences in individual taxa between control subjects and IC/BPS participants [55][56][57], but did observe trends towards differential abundances of several species, such as increased L. gasseri and lower Corynebacterium prevalence in IC/BPS patients. Earlier studies using both voided and catheterized specimens are similar, visualizing overall changes in diversity without unique disease-associated species.…”

Section: Genitourinary Pain (Ic/bps and Cp/cpps)-for Genitourinary Pamentioning

confidence: 99%

The Bladder is Not Sterile: an Update on the Urinary Microbiome

Ackerman

Chai

2019

Curr Bladder Dysfunct Rep

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Purpose of Review-The article discusses (1) techniques used to study bacterial urinary microbiota; (2) existence of non-bacterial urinary microbiota; (3) associations between changes in urinary microbiota and various benign lower urinary tract disorders. Recent Findings-Urine harbors a diverse microbial community that resides within it. A multitude of studies have identified differences in these communities associated with urologic conditions, suggesting that microbial communities may maintain normal bladder homeostasis. Technological advances in analytic approaches have improved our understanding of the urinary microbiome. The choice of urine sampling method (voided, catheterized, or aspirated) will significantly influence microbiome findings. Sex and age highly influence urinary microbiota; in addition to rigorous inclusion criteria, microbial studies must be sufficiently powered to overcome the substantial interindividual variability of urinary microbiota. Regardless of these complicating factors, studies have identified microbial patterns correlating with both urologic diagnoses and treatment responses. Summary-Without a clear understanding of the variability of and exogenous influences on the urinary microbiota in the absence of disease, it has been challenging to reveal the microbial patterns responsible for disease pathophysiology. Host mechanisms in response to the urinary microbiome are also poorly understood. Additional research can address whether the manipulation of urinary microbiota will benefit lower urinary tract health.

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Female lower urinary tract microbiota do not associate with IC/PBS symptoms: a case-controlled study

Cited by 40 publications

References 19 publications

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome

Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome

Biomarker discovery and beyond for diagnosis of bladder diseases

The Bladder is Not Sterile: an Update on the Urinary Microbiome

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