Female prostate in the house rat Rattus rattus

Shehata, Ramzy

doi:10.1159/000143878

Cited by 13 publications

(10 citation statements)

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“…Fibroblasts and smooth muscle cells (thick arrows); epithelial cell nuclei (arrows). (Brambell and Davis, 1940;Mahoney and Witschi, 1947;Shehata, 1972Shehata, , 1975Shehata, , 1980Gross and Didio, 1987;Satoh et al, 2001;Flamini et al, 2002;Santos et al, 2003Santos et al, , 2007. In the gerbil Meriones unguiculatus, the prostate is found in $ 80% of the animals , a proportion very similar to that in human females (Zaviacic, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In the gerbil Meriones unguiculatus, the prostate is found in $ 80% of the animals , a proportion very similar to that in human females (Zaviacic, 1999). For the rats, the presence of a prostate in females is variable, occurring in Rattus rattus, Wistar (Rattus norvegicus; Mahoney and Witschi, 1947;Shehata, 1972), and Brown-Norway lineages (Satoh et al, 2001). Besides the interspecific variation, Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The prostate gland is not an organ exclusive to the male reproductive system as it has been found in females of some mammalian species including some rodents (Mahoney and Witschi, 1947;Price, 1963;Shehata, 1972Shehata, , 1980 and humans (Zaviacic, 1999). The female prostate, historically know as Skene's gland, is located around the urethra at the bladder base.…”

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confidence: 99%

“…Studies by Shehata (1972) on the female prostate of experimental rodents have indicated that this gland can be found both in Rattus rattus and Rattus norvegicus. Mahoney and Witschi (1947) observed that wild female albino Wistar rats showed prostate glands at an approximate frequency of 29%, could be greatly increased by selective inbreeding to a 99%.…”

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confidence: 99%

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Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Biancardi

Santos

Madi-Ravazzi

et al. 2010

The Anatomical Record

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The female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. On the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Biancardi

Santos

Madi-Ravazzi

et al. 2010

The Anatomical Record

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“…Although the prostate gland is one of the accessory genital glands of the male, it has been reported that a rudimentary prostate gland is occasionally seen in female rats [5,7,11] . Furthermore, it has been demonstrated that a well-developed prostate is present in female Mastomys [1,8,9] .…”

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confidence: 99%

Histological Observation on the Female Prostate in Mongolian Gerbils (<I>Meriones unguiculatus</I>)

Inomata

Ninomiya²,

Somiya

et al. 1992

Experimental Animals

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Female prostate: historical, developmental, and morphological perspectives

Biancardi

Santos

Carvalho

et al. 2017

Cell Biology International

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The female prostate was first described by Reijnier de Graaf in 1672, and even after several years this gland is still a matter of controversy. Part of this is because the biological function of this female gland is unclear. Moreover, when compared with the male prostate, the existence of this organ in females does not make sense, mainly when we consider that the major function of this gland is to produce a secretion that is responsible for guarantee the sperm survival and assure the reproductive success. However, even under a controversy field, we now have a lot of scientific information which enhances our knowledge of several important biological aspects of this gland. It is clear that this gland is found in some female mammals including humans, rodents, rabbits, bats, and dogs. Several studies with rodents showed that the female prostate is homolog of the male prostate, showing strong macroscopic and microscopic similarities with the ventral lobe of males. Besides these aspects, there are several studies reporting that diseases such as cysts, hyperplasia, and carcinoma may affect the female prostate. Therefore, although diseases involving the female prostate are rare, the susceptibility of this organ to develop lesions must be considered, especially in our recent years in which the exposure to endocrine-disrupting chemicals has greatly increased. Finally, further studies will be necessary to enhance our understanding about this gland, mainly of the developmental, evolutionary, and biological functions.

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Female prostate in the house rat Rattus rattus

Cited by 13 publications

References 1 publication

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Histological Observation on the Female Prostate in Mongolian Gerbils (<I>Meriones unguiculatus</I>)

Female prostate: historical, developmental, and morphological perspectives

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