Femtosecond spectroscopic study of carminic acid–DNA interactions

Comanici, Radu; Gabel, Bianca; Gustavsson, T.; Markovitsi, Dimitra; Cornaggia, C.; Pommeret, S.; Rusu, C.S.; Kryschi, Carola

doi:10.1016/j.chemphys.2006.01.026

Cited by 11 publications

(5 citation statements)

References 21 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Deconvolution of the emission spectrum also results in two distinct Gaussian components at 16 180 (Δν 1/2 = 2140 cm −1 ) and 17 070 cm −1 (Δν 1/2 = 1170 cm −1 ), which can be attributed to LE and ICT emissions, respectively (Figure a). Weak band at 14200 cm −1 can be attributed to the traces of carminic acid monoanion. , …”

Section: Resultsmentioning

confidence: 99%

“…It was also used recently for preparation of red silica glasses using sol−gel method . Because of its specific interactions with proteins, nucleic acids, and lipids, carminic acid also found numerous applications in biochemical studies. Structure of the carminic acid molecule suggests strong covalent binding via carboxylic and/or hydroxyl functionalities.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Photosensitization and Photocurrent Switching in Carminic Acid/Titanium Dioxide Hybrid Material

2008

View full text Add to dashboard Cite

New photoactive material is obtained by chemisorption of carminic acid onto nanocrystalline titanium dioxide. Organic chromophore is anchored at the semiconductor surface via the neighboring carboxylate and phenolate groups; the anchorage is strengthened by formation of the six-membered chelate ring. Photoelectrochemical studies reveal strong photosensitization of the new material toward visible light: The photoelectrodes comprised of carminic acid-titanium dioxide hybrid material generate photocurrent within 300-650 nm window. Moreover, the direction of the photocurrent can be changed from anodic to cathodic and vice versa by application of appropriate photoelectrode potential, changes in electrolyte composition, and incident light wavelength. Geometry, electronic structure, and the photophysics of the neat chromophore and its model complex with Ti IV oxo-species are studied in detail using the density functional theory method. Photoelectrochemical and spectroscopic studies supplemented with quantum-chemical modeling allow elucidation of photocurrent switching mechanism. The carminic acid-titanium dioxide material constitutes an efficient platform for light harvesting antennae, optoelectronic switches, and other optoelectronic devices.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photosensitization and Photocurrent Switching in Carminic Acid/Titanium Dioxide Hybrid Material

2008

View full text Add to dashboard Cite

show abstract

“…Although CarOH cannot bind to DNA,5 it can suppress the genotoxic activities of several mutagens in the Drosophila DNA repair test and in the Ames test 6. Recently, CarOH is found to be a ligand to form a complex with DNA and to be a molecular probe in femtosecond spectroscopic study on DNA 7. CarOH can produce superoxide anion when it is oxidized by Agaricus bisporus tyrosinase 8.…”

Section: Introductionmentioning

confidence: 99%

Carminic acid: an antioxidant to protect erythrocytes and DNA against radical‐induced oxidation

Liu

2009

J of Physical Organic Chem

View full text Add to dashboard Cite

This work explored the antioxidant effect of carminic acid (CarOH) on the oxidation of DNA and erythrocytes induced by 2,2′‐azobis(2‐amidinopropane hydrochloride) (AAPH). The half concentrations (IC50) of CarOH to scavenge radicals were measured by reacting with 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonate) radical cation (ABTS+•) and 2,2′‐diphenyl‐1‐picrylhydrazyl (DPPH). The values of IC50 were 8.0 and 26.0 µM when CarOH reacted with ABTS+• and DPPH, respectively. CarOH was able to protect DNA against AAPH‐induced oxidative damage by decreasing the formation rate of thiobarbituric acid reactive substance (TBARS). In addition, CarOH protected human erythrocytes against AAPH‐induced hemolysis concentration dependently, during which one molecule of CarOH can trap almost three radicals. Moreover, quantum calculation revealed that the hydroxyl group at 6‐position played major role in trapping radicals. Copyright © 2009 John Wiley & Sons, Ltd.

show abstract

“…Physical analysis methods, generally non-destructive, as-sume the interaction of the substance with radiation of a certain energy. The optical properties of organic molecules can be examined using stationary techniques such as spectroscopy that is a method based on the property of substances to selectively absorb electromagnetic radiation, therefore in the last several years, it has become possible to directly observe the dynamics of excited electronic states in DNA model compounds by femtosecond spectroscopy [8]. In the case of the interaction of radiation with the substance, transitions are present due to the absorption of energy by the molecules.…”

Section: Uv-vis Spectroscopy Study Of 254 Nm Wavelength Irradiation O...mentioning

confidence: 99%

"Action Of UV-C Radiation for Biomolecules Inactivation, With Application in Diagnostics"

Ion

2023

BJSTR

View full text Add to dashboard Cite

The action of UV-C radiation for the decontamination of pathogens is a very actual subject to be studied, as a result of the recent pandemic , in finding new effective methods of inactivating pathogens (viruses, bacteria, etc.) with their application in diagnostics. The effects of UV radiation with a 254 nm wavelength on the DNA elements of yeast fungi are observed and analysed in this communication. Quick information about the dose of radiation applied and the level of inactivation of pathogens is necessary, and spectroscopy methods can be of great help in this regard. By using spectroscopy analysis methods, the strong correlation between the decontamination rate and absorption spectra of yeast solution was find. This relationship between the spectrum and the pathogen decontamination rate can be successfully used in diagnostics of pathogens such as Candida Albinus, which is more resistant than a class of viruses and bacteria, including COVID-19.

show abstract

Femtosecond spectroscopic study of carminic acid–DNA interactions

Cited by 11 publications

References 21 publications

Photosensitization and Photocurrent Switching in Carminic Acid/Titanium Dioxide Hybrid Material

Photosensitization and Photocurrent Switching in Carminic Acid/Titanium Dioxide Hybrid Material

Carminic acid: an antioxidant to protect erythrocytes and DNA against radical‐induced oxidation

"Action Of UV-C Radiation for Biomolecules Inactivation, With Application in Diagnostics"

Contact Info

Product

Resources

About