FEN1 knockdown improves trastuzumab sensitivity in human epidermal growth factor 2-positive breast cancer cells

Zeng, Xue; Che, Xiaofang; Liu, Yunpeng; Qu, Xiujuan; Zhao, Chenyang; Zheng, Chunlei; Hou, Kezuo; Teng, Yuee

doi:10.3892/etm.2017.4873

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…Similarly, knock out of FEN1 enhances the sensitivity of gastric cancer cells to cisplatin (7). As reported in breast cancer, FEN1 is related to the resistance of trastuzumab, tamoxifen, temozolomide, uorouracil, cisplatin and other chemotherapeutics drugs (29,36,37). Research published by Li JL suggested that inhibitors against FEN1 increase the sensitivity of cervical cancer cells to ionizing radiation therapy (30).…”

Section: Discussionmentioning

confidence: 88%

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

Wei

Shen

Wang

et al. 2021

Preprint

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Background: Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers. There is a lack of systematic bibliometric analyses focusing on research trends and knowledge structures related to FEN1.Purpose: To analyze hotspots, the current state and research frontiers performed for FEN1 over the past 15 years. Methods: Publications were retrieved from the Web of Science Core Collection (WoSCC) database, analyzing publication dates ranging from 2005 to 2019. VOSviewer1.6.15 and Citespace5.7 R1 were used to perform a bibliometric analysis in terms of countries, institutions, authors, journals and research areas related to FEN1. A total of 421 publications were included in this analysis. Results: Our findings indicated that FEN1 has received more attention and interest from researchers in the past 15 years. Institutes in the United States, specifically the Beckman Research Institute of City of Hope published the most research related to FEN1. SHEN BH，ZHENG L and BAMBARA RA were the most active researchers investigating this endonuclease and most of this research was published in the Journal of Biological Chemistry. The main scientific areas of FEN1 were related to biochemistry, molecular biology，cell biology，genetics and oncology. Research hotspots included biological activities, DNA metabolism mechanisms, protein-protein interactions and gene mutations. Research frontiers included oxidative stress, phosphorylation and tumor progression and treatment. Conclusion: This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with FEN1. In addition, emerging hotspots for research can be used as the subjects of future studies.

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Section: Discussionmentioning

confidence: 88%

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

Wei

Shen

Wang

et al. 2021

Preprint

Self Cite

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show abstract

“…Similarly, knock out of FEN1 enhances the sensitivity of gastric cancer cells to cisplatin [ 8 ]. As reported in breast cancer, FEN1 is related to the resistance of trastuzumab, tamoxifen, temozolomide, fluorouracil, cisplatin and other chemotherapeutics drugs [ 31 , 38 , 39 ]. Research published by Li JL suggested that inhibitors against FEN1 increase the sensitivity of cervical cancer cells to ionizing radiation therapy [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of researches on flap endonuclease 1 from 2005 to 2019

et al. 2021

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Background Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. It is associated with the occurrence and development of several diseases, especially cancers. There is a lack of systematic bibliometric analyses focusing on research trends and knowledge structures related to FEN1. Purpose To analyze hotspots, the current state and research frontiers performed for FEN1 over the past 15 years. Methods Publications were retrieved from the Web of Science Core Collection (WoSCC) database, analyzing publication dates ranging from 2005 to 2019. VOSviewer1.6.15 and Citespace5.7 R1 were used to perform a bibliometric analysis in terms of countries, institutions, authors, journals and research areas related to FEN1. A total of 421 publications were included in this analysis. Results Our findings indicated that FEN1 has received more attention and interest from researchers in the past 15 years. Institutes in the United States, specifically the Beckman Research Institute of City of Hope published the most research related to FEN1. Shen BH, Zheng L and Bambara Ra were the most active researchers investigating this endonuclease and most of this research was published in the Journal of Biological Chemistry. The main scientific areas of FEN1 were related to biochemistry, molecular biology, cell biology, genetics and oncology. Research hotspots included biological activities, DNA metabolism mechanisms, protein-protein interactions and gene mutations. Research frontiers included oxidative stress, phosphorylation and tumor progression and treatment. Conclusion This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with FEN1. In addition, emerging hotspots for research can be used as the subjects of future studies.

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“…FEN1 has been identified as a potential biomarker from previous studies, which found that overexpression of FEN1 could disrupt the cell cycle and promote cell proliferation in numerous types of cancer, including breast cancer ( 13 , 24 , 35 , 36 ). Furthermore, FEN1 overexpression was also associated with resistance to chemotherapy ( 18 , 22 ), and targeted therapy ( 37 ). In addition, some early studies showed that high FEN1 expression was associated with aggressive phenotypes in patients with breast, ovarian or prostate cancer ( 9 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis

Song

Zhang

et al. 2020

Oncol Rep

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Flap endonuclease-1 (FEN1), a structure-specific nuclease participating in DNA replication and repair processes, has been confirmed to promote the proliferation and drug resistance of tumor cells. However, the biological functions of FEN1 in cancer cell migration and invasion have not been defined. In the present study, using online database analysis and immunohistochemistry of the specimens, it was found that FEN1 expression was associated with a highly invasive triple-negative breast cancer (TNBC) subtype in both breast cancer samples from the Oncomine database and from patients recruited into the study. Furthermore, FEN1 was an important biomarker of lymph node metastasis and poor prognosis in patients with TNBC. FEN1 promoted migration of TNBC cell lines and FEN1 knockdown reduced the number of spontaneous lung metastasis in vivo . Ingenuity Pathway Analysis of FEN1-related transcripts in 198 patients with TNBC demonstrated that the polo-like kinase family may be the downstream target of FEN1. PLK4 was further identified as a critical target of FEN1 mediating TNBC cell migration, by regulating actin cytoskeleton rearrangement. The results of the present study validate FEN1 as a therapeutic target in patients with TNBC and revealed a new role for FEN1 in regulating TNBC invasion and metastasis.

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FEN1 knockdown improves trastuzumab sensitivity in human epidermal growth factor 2-positive breast cancer cells

Cited by 10 publications

References 47 publications

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019

A bibliometric analysis of researches on flap endonuclease 1 from 2005 to 2019

Biological and clinical significance of flap endonuclease‑1 in triple‑negative breast cancer: Support of metastasis and a poor prognosis

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