Fenbendazole: A new, highly effective anthelmintic

Baeder, Christian; Bahr, Hoda I.; Christ, O; Düwel, D.; Kellner, H. M.; Kirsch, R.; Loewe, H; Schultes, E; Schütz, Erich; Westen, H.

doi:10.1007/bf01924165

Cited by 53 publications

(16 citation statements)

References 2 publications

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“…Parbendazole (Actor et al, 1967), mebendazole (Van den Bossche, 1972), oxibendazole (Theodorides * The following common names are used: thiabendazole, 2-(4'-thiazolyl)benzimidazole; benomyl, methyl l-(butylcarbamoyl)benzimidazol-2-yl carbamate; carbendazim, methyl benzimidazol-2-yl carbamate; fuberidazole, 2-(2'-furyl) benzimidazole; fenbendazole, methyl 5-(phenylthio)benzimidazol-2-yl carbamate; mebendazole, methyl 5-benzoylbenzimidazol-2-yl carbamate; oxibendazole, methyl 5-n-propoxybenzimidazol-2-yl carbamate; parbendazole, methyl 5-butyl benzimidazol-2-yl carbamate and oncodazole, 5-(2-thienylcarbonyl)benzimidazol-2-yl carbamate. et al, 1973) and fenbendazole (Baeder et al, 1974) have anthelmintic properties and are used in veterinary medicine. Oncodazole has been described as being active against tumors in mammals including man De Brabander et al, 1975).…”

Section: Survey Of the Literaturementioning

confidence: 98%

Mode of action, selectivity and mutagenicity of benzimidazole compounds

Davidse

1977

Neth. J. Pl. Path.

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Section: Survey Of the Literaturementioning

confidence: 98%

Mode of action, selectivity and mutagenicity of benzimidazole compounds

Davidse

1977

Neth. J. Pl. Path.

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“…Fenbendazole (FBZ), a benzimidazole anthelmintic, is a veterinary treatment for nematodes and cestodes in domestic animals, birds and livestock (Baeder et al . ; Kirsch ; Ngomuo, Marriner & Bogan ). FBZ binds to tubulin, disrupting microtubule function and causing parasite detachment from the host (Kohler ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell)

Forwood

Harris

Deveney

2013

Journal of Fish Diseases

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We investigated the efficacy of praziquantel (PZQ) and fenbendazole (FBZ), each administered by bath and orally, against the monogenean Lepidotrema bidyana Murray, a gill parasite of the freshwater fish silver perch, Bidyanus bidyanus (Mitchell). PZQ and FBZ were each administered by bath at 10 mg L⁻¹ for 48 h and on surface-coated feed pellets at 75 mg kg⁻¹ per body weight (BW) per day for 6 days. Bath treatments of PZQ and FBZ had an efficacy of 99% and 91%, respectively, against adult L. bidyana. Oral treatments of PZQ and FBZ had an efficacy of 79% and 95%, respectively, against adult L. bidyana. Fish rejected feed pellets surface-coated with PZQ, suggesting that palatability of surface-coated PZQ-medicated feed is poor, which undermined efficacy. In all trials, some juvenile parasites were present on fish after treatment during efficacy assessment, indicating that efficacy may be lower against juvenile parasites or that recruitment occurred post-treatment, demonstrating that repeat treatments are necessary to effectively control L. bidyana in aquaculture.

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“…INTRODUCTION FENBENDAZOLE* (methyl 5-(phenylthio)-2-benzimidazole-carbamate) has been shown to be a well tolerated anthelmintic and to be highly efficient against nematode infections in laboratory and domestic animals (Baeder, et al, 1974). The broad spectrum of activity of this compound has been confirmed against nematode species occurring in cattle (Duwel and Kirsch, 1975;Enigk, Dey-Hazra and Batke, 1975;Todd, Bliss, Scholl and Crowley, 1976), sheep (Kirsch and Duwel, 1975a;Ross, 1975;Kennedy and Todd, 1975) and pigs (Kirsch and Duwel, 1975b).…”

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The Efficacy of Fenbendazole in the Control of Immature Strongyle Infections in Ponies

Duncan

McBeath²,

Best³

et al. 1977

Equine Veterinary Journal

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SUMMARY The efficacy of fenbendazole against immature stages of Trichonema spp., Strongylus vulgaris and Strongylus edentatus was evaluated. Naturally infected 6 to 12 month old ponies were given single, oral doses of 0, 15, 30 and 60 mg/kg of body weight. A dose response relationship was noted between increasing dose levels and efficiency against larval trichonemes and migrating stages of S. vulgaris and S. edentatus. Dose levels of 30 mg/kg and higher removed 93 per cent of mucosal stages of Trichonema spp., while doses of 60 mg/kg removed 83 per cent and 89 per cent of the migrating larvae of S. vulgaris and S. edentatus respectively. RÉSUMÉ On a évalué l'efficacité du fenbendazole sur les stades larvaires de St Vulgaris, St edentatus et Trichonema spp. Des poneys naturellement infectés âgés de 6 à 12 mois reçurent des doses orales de 15, 30 et 60 mg/kg de poids vif de fenbendazole. L'efficacité sur les stades larvaires parut dépendre de la dose administrée. Des taux de 30 mg et au dessus détruisirent 93% des larves intra muqueuses de Trichonema tandis que des doses de 60 mg/kg détruisaient 83% des larves migrantes de St vulgaris et 89% des larves migrantes de Str edentatus. ZUSAMMENFASSUNG Die Wirksamkeit von Fenbendazol gegen unreife Stadien von Trichonema spp., Strongylus vulgaris und Strongylus edentatus wurde untersucht. Natürlich infizierte Ponies im Alter zwischen 6 und 12 Monaten erhielten orale Einzeldosen von 0, 15, 30 und 60 mg pro kg Körpergewicht. Eine Beziehung zwischen Dosis und Wirkung gegen Trichonemalarven und Wanderlarven von S. Vulgaris und S. edentatus konnte beobachtet werden. Dosierungen von über 30 mg/kg vermochten 93% der Schleimhautstadien von Trichonema zu entfernen, während Dosierungen von 60 mg/kg 83 bzw. 89% der Wanderlarven von S. vulgaris und S. edentatus abtöteten.

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Fenbendazole: A new, highly effective anthelmintic

Cited by 53 publications

References 2 publications

Mode of action, selectivity and mutagenicity of benzimidazole compounds

Mode of action, selectivity and mutagenicity of benzimidazole compounds

Efficacy of bath and orally administered praziquantel and fenbendazole against Lepidotrema bidyana Murray, a monogenean parasite of silver perch, Bidyanus bidyanus (Mitchell)

The Efficacy of Fenbendazole in the Control of Immature Strongyle Infections in Ponies

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