Fenfluramine challenge test predicts outcome in pharmacological treatment of patients with functional gastrointestinal disorder

Gender, aggression and serotonergic function are associated with response to sertraline for behavioral disturbances in Alzheimer's disease

“…Central serotonergic tone as assessed by fenfluramine challenge had not previously been assessed as a predictor of response to treatment in this population. Fenfluramine challenge has predicted outcome to antidepressants in major depression (Malone et al, 1993;Cleare et al, 1998), haloperidol in acute schizophrenia (Mohr et al, 1998) and mianserin in nonpsychiatric patients (Tanum et al, 1999), but not to SSRIs in another study of major depression (Park et al, 1995). Thus, fenfluramine challenge may be able to distinguish subtypes of BPSD.…”