Fennel-like nanoaggregates based on polysaccharide derivatives and their application in drug delivery

Song, Fei; Shi, Wen-Ting; Dong, Xue-Ting; Han, Xue; Wang, Xiuli; Chen, Si‐Chong; Wang, Yu‐Zhong

doi:10.1016/j.colsurfb.2013.09.027

Cited by 9 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The semi‐empirical Korsmeyer–Peppas equation (Eqs. ) was used to further analyze the accumulative release data at pH 6 and pH 7.4:

true M_{t} / M_{\infty} = k \times t^{n}

true \lg (M_{t} / M_{\infty}) = \lg k + n \lg t

…”

Section: Resultsmentioning

confidence: 99%

“…Considering that the extracellular pH between cancerc ells and normal cells is different, an acidic solution( pH 6.0) and PBS buffer solution (pH 7.4) werec hosen to simulate the microenvironment of cancer cells and normal physiological media, respectively.A se xpected, ar apid cumulative release ratio of 48.5 %o ft he rGO/(PLL/PASP) 3 @DOX nanocomposite was observed in acidic solution (pH 6) within 24 h, as shown in Figure 3B 1) and (2)) [40][41][42] was used to further analyze the accumulativer elease data at pH 6a nd pH 7.4:…”

Section: Film (Figures3)mentioning

confidence: 98%

See 1 more Smart Citation

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Zhang

Meng

et al. 2018

Chemistry A European J

View full text Add to dashboard Cite

The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO)-polymer self-assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO-polymer carriers were constructed by the alternating assembly of poly-l-lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO-polymer bilayers and concentration of the rGO-polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH-responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.

show abstract

“…The semi‐empirical Korsmeyer–Peppas equation (Eqs. ) was used to further analyze the accumulative release data at pH 6 and pH 7.4:

true M_{t} / M_{\infty} = k \times t^{n}

true \lg (M_{t} / M_{\infty}) = \lg k + n \lg t

…”

Section: Resultsmentioning

confidence: 99%

Section: Film (Figures3)mentioning

confidence: 98%

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Zhang

Meng

et al. 2018

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…The aqueous dispersion of Py‐PPDO 12 ‐b‐PEG 45 /MWCNTs was stable and homogeneous with a dark ink‐like appearance and remained unchanged at least for one month (Figure b). The amphiphilic copolymer of PPDO can form “star anise”‐like anisotropic nanoparticles in water because of the crystallization of PPDO blocks . Interestingly, in this work, owing to the introduction of pyrene moieties to the PPDO‐b‐PEG copolymer, the Py‐PPDO 12 ‐b‐PEG 45 and MWCNTs formed some “shish kebab”‐like hierarchical composite micelles with MWCNTs as the “shish” and anisotropic semicrystalline micelles of Py‐PPDO 12 ‐b‐PEG 45 as “kebab” (Figure B).…”

Section: Resultsmentioning

confidence: 66%

Preparation of Core–Shell Nanofibers with Selectively Localized CNTs from Shish Kebab‐like Hierarchical Composite Micelles

Liu

Wang

et al. 2014

Macromol. Rapid Commun.

Self Cite

View full text Add to dashboard Cite

A novel and facile bottom-up strategy for preparing core-shell nanofibers with selectively localized carbon nanotubes is developed using hierarchical composite micelles of crystalline-coil copolymer and carbon nanotubes as the building blocks. An amphiphilic di-block copolymer of poly (p-dioxanone) (PPDO) and PEG (polyethylene glycol) functionalized with pyrene moieties at the chain ends of PPDO blocks (Py-PPDO-b-PEG) is designed for constructing composite micelles with multiwalled carbon nanotubes (MWCNTs). The self-assembly of Py-PPDO-b-PEG and MWCNTs is co-induced by the crystallization of PPDO blocks and the π-π stacking interactions between pyrene moieties and MWCNTs, resulting in composite micelles with "shish kebab"-like nanostructure. A mixture of composite micelles and polyvinyl alcohol (PVA) water solution is then used as the spinning solution for preparing electrospun nanofibers. The morphologies of the nanofibers with different composition are investigated by SEM and TEM. The results suggest that the MWCNTs selectively localized in the core of the nanofibers of MWCNTs/Py-PPDO-b-PEG/PVA. The alignment and interfusion of composite micelles during the formation of nanofibers may confine the carbon nanotubes in the hydrophobic core region. In contrast, the copolymer without pyrene moieties cannot form composite micelles, thus these nanofibers show selective localization of MWCNTs in the PVA shell region.

show abstract

Hydrogels

Veiga

Ruíz-Caro

Notario-Pérez

et al. 2018

Design and Development of New Nanocarriers

View full text Add to dashboard Cite

Fennel-like nanoaggregates based on polysaccharide derivatives and their application in drug delivery

Cited by 9 publications

References 33 publications

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Preparation of Core–Shell Nanofibers with Selectively Localized CNTs from Shish Kebab‐like Hierarchical Composite Micelles

Hydrogels

Contact Info

Product

Resources

About

Fennel-like nanoaggregates based on polysaccharide derivatives and their application in drug delivery

Cited by 9 publications

References 33 publications

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Preparation of Core–Shell Nanofibers with Selectively Localized CNTs from Shish Kebab‐like Hierarchical Composite Micelles

Hydrogels

Contact Info

Product

Resources

About

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy