Fentanyl - A Potent Opioid Analgesic: A Review

Sharma, Ashok K.; Nareda, Maniratna; Aziz, Sanaa; Sharma, Deepak; Garg, Shiv

doi:10.4172/2329-6631.1000162

Cited by 9 publications

(11 citation statements)

References 39 publications

(25 reference statements)

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“…The thermal curve measured during TGA analysis of the fresh and degraded fentanyl is shown in Figure 4. For both powder types, a single mass-loss event was observed to begin at 232°C, which is the reported melting temperature for fentanyl HCl [15].…”

Section: Thermal Gravimetric Analysis/differential Scanning Calorimetrymentioning

confidence: 73%

Characterization of fentanyl HCl powder prior to and after systematic degradation

Ciesielski

Simon

Welch

et al. 2022

Journal of Forensic Sciences

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Fentanyl HCl is of particular interest in forensic cases but there is a notable gap in literature regarding its analysis. This study utilized a multi-method approach to characterize fentanyl HCl powder, both fresh and following a forced degradation process. Using sensitive liquid chromatography-tandem mass spectrometry (LC-MS/ MS) and direct injection gas chromatography-mass spectrometry (GC-MS), five

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Section: Thermal Gravimetric Analysis/differential Scanning Calorimetrymentioning

confidence: 73%

Characterization of fentanyl HCl powder prior to and after systematic degradation

Ciesielski

Simon

Welch

et al. 2022

Journal of Forensic Sciences

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“…This morphinomimetic interacts mainly with presynaptic µ-opioid receptor of the central nervous system (review in Stanley, 2014 ). Its physicochemical characteristics allow it to cross the blood–encephalic barrier ( Terenius, 1974 ) and make it suitable for delivery by a transdermal therapeutic system ( Sharma et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Long-Lasting Analgesia With Transdermal Fentanyl: A New Approach in Rat Neonatal Research

Dutriez-Casteloot

Emmanuelli

Wiart³

et al. 2022

Front. Pharmacol.

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Background: With advances in neonatal care, management of prolonged pain in newborns is a daily concern. In addition to ethical considerations, pain in early life would have long-term effects and consequences. However, its treatment remains inadequate. It was therefore important to develop an experimental model of long-lasting analgesia for neonatal research.Materials and Methods: Experiments were performed in six groups of rats with transdermal fentanyl 0, 3, 12, 50, 100, or 200 μg/kg/h from second postnatal day (P2) until weaning. Assessment of analgesia was carried out at P21, with behavioral scores (ranging from 0 to 3) using a 4% formalin test. Plasma levels of fentanyl were determined by UPLC/TQD at P22. Growth rate was investigated.Results: Fentanyl 100 and 200 μg/kg/h reduced scores of formalin-evoked behavioral pain. They increased time spent in pain score 0 (8 min 55 s and 6 min 34 s versus 23 s in controls) as in low pain scores 1 and 2, and decreased time in the most severe pain score 3 (19 min 56 s and 17 min 39 s versus 44 min 15 s). Fentanylemia increased in a dose-dependent manner from 50 μg/kg/h (2.36 ± 0.64 ng/ml) to 200 μg/kg/h (8.66 ± 1.80 ng/ml). Concerning growth, no difference was observed except weaker growth from P17 to P22 with 200 μg/kg/h. Clinically, we noticed no visible side effect from 3 to 100 μg/kg/h. Concomitantly, 200 μg/kg/h was responsible for ophthalmological side effects with appearance of corneal bilateral clouding in 90% pups. No difference was observed between male and female rats.Conclusion: Altogether, results indicate that transdermal fentanyl 100 μg/kg/h is an efficient therapeutic for long-lasting analgesia in lactating pups. This new model provides a useful tool for protection and welfare, and future opportunity for studying long-term health consequences of sustainable neonatal analgesia.

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“…Semi-synthetic and synthetic opioids used for treatment (e.g., codeine, hydrocodone, oxycodone, fentanyl and its analogs, tramadol, tapentadol, etc.) are very effective drugs for managing severe acute pain, cancer pain, and, in some cases, chronic non-tumor pain [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The risk is associated with dose-dependent respiratory depression, a common cause of death in the case of fatal intoxication [ 5 , 9 , 10 , 25 , 26 ]. The other symptoms of NSOs intoxication include, e.g., nausea, vomiting, constipation, sedation, cognitive impairment, and pruritus [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Electroanalysis of Fentanyl and Its New Analogs: A Review

et al. 2022

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The review describes fentanyl and its analogs as new synthetic opioids and the possibilities of their identification and determination using electrochemical methods (e.g., voltammetry, potentiometry, electrochemiluminescence) and electrochemical methods combined with various separation methods. The review also covers the analysis of new synthetic opioids, their parent compounds, and corresponding metabolites in body fluids, such as urine, blood, serum, and plasma, necessary for a fast and accurate diagnosis of intoxication. Identifying and quantifying these addictive and illicit substances and their metabolites is necessary for clinical, toxicological, and forensic purposes. As a reaction to the growing number of new synthetic opioid intoxications and increasing fatalities observed over the past ten years, we provide thorough background for developing new biosensors, screen-printed electrodes, or other point-of-care devices.

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Fentanyl - A Potent Opioid Analgesic: A Review

Cited by 9 publications

References 39 publications

Characterization of fentanyl HCl powder prior to and after systematic degradation

Characterization of fentanyl HCl powder prior to and after systematic degradation

Long-Lasting Analgesia With Transdermal Fentanyl: A New Approach in Rat Neonatal Research

Electroanalysis of Fentanyl and Its New Analogs: A Review

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