2003
DOI: 10.1007/bf03020183
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Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine

Abstract: P Pu ur rp po os se e: : To present and discuss a case of opioid-induced rigidity with low-dose fentanyl during recovery from anesthesia.C Cl li in ni ic ca al l f fe ea at tu ur re es s: : A 41-yr-old woman underwent laparotomy for total abdominal hysterectomy and bilateral salpingo-oophorectomy under general anesthesia. She received a total of 500 µg of fentanyl by iv intermittent boluses during the three-hour anesthetic. During emergence from anesthesia, while intubated, the patient presented with rigidity.… Show more

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Cited by 49 publications
(31 citation statements)
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“…A recent human case report noted muscle rigidity in a patient chronically taking venlafaxine after she was given i.v. fentanyl during surgery (though she had also received a single dose of intramuscular meperidine just before the procedure) (14). That patient's physical examination was significant for hyperreflexia and ankle clonus.…”
Section: Discussionmentioning
confidence: 98%
“…A recent human case report noted muscle rigidity in a patient chronically taking venlafaxine after she was given i.v. fentanyl during surgery (though she had also received a single dose of intramuscular meperidine just before the procedure) (14). That patient's physical examination was significant for hyperreflexia and ankle clonus.…”
Section: Discussionmentioning
confidence: 98%
“…30,31 Severe reactions and fatalities have been reported with pethidine, tramadol and fentanyl. 32 The fatal outcome in the Libby Zion case is widely attributed to severe serotonin toxicity as a result of administration of pethidine while she was taking phenelzine. 3 Morphine analogues (morphine, codeine, dihydrocodeine, buprenorphine) do not inhibit serotonin reuptake and serotonin toxicity has not been reported with those drugs.…”
Section: Antibacterial Drugsmentioning
confidence: 99%
“…Although MH may occur postoperatively, it is unlikely that fever alone characterizes MH 25 . Another cause for excluding MH diagnosis in hotline calls in 2009 was an isolated reaction characterized by muscle rigidity after opioid use, a rare event associated with high doses, which occurs during induction or recovery and may show improvement after naloxone or neuromuscular block 26 . Regarding MH episode presentation in our country, there are similarities with those reported in other countries.…”
Section: Figure 2 In Vitro Muscle Contracture Test In Response Tomentioning
confidence: 99%