Fenugreek (Trigonella foenum graecum L.) supplementation safeguards male mice from aflatoxin B1-induced liver and kidney damage

El-Hak, Heba Nageh Gad; Metawea, Shimaa Ibrahim; Nabil, Zohour I.

doi:10.1007/s00580-022-03413-6

Cited by 5 publications

(2 citation statements)

References 73 publications

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“…Fenugreek has been shown to exert hepatoprotective and nephroprotective effects by reducing lipid peroxidation levels in the liver and kidney, in addition to enhancing cellular antioxidant defense in rats [ 172 , 173 , 174 ]. To evaluate the effect of fenugreek on AFB1-induced damage to the liver and kidney, male albino mice received AFB1 (20 µg/kg) followed by fenugreek (200 mg/kg/day) [ 84 ]. AFB1 caused liver and kidney damage in addition to alterations in some hematological parameters that were manifested by increased oxidative damage, a substantial reduction in antioxidant capacity, and increased kidney histopathological findings.…”

Section: Herbal Productmentioning

confidence: 99%

“…In the fenugreek groups, a significant decline was observed in BUN, UA, and CRE levels, together with an improvement in kidney histological and cellular structures. In addition, the treatment ameliorated the levels of MDA, total antioxidant enzyme activities, and GSH in the kidney and liver [ 84 ]. In this regard, fenugreek seed supplementation could be recommended as a regular nutrient for the liver [ 175 ] and for kidney protection against aflatoxin toxicity and other nephrotoxic agents.…”

Section: Herbal Productmentioning

confidence: 99%

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Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

Ofori-Attah,

Hashimoto,

Oki

et al. 2024

IJMS

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Aflatoxins are harmful natural contaminants found in foods and are known to be hepatotoxic. However, recent studies have linked chronic consumption of aflatoxins to nephrotoxicity in both animals and humans. Here, we conducted a systematic review of active compounds, crude extracts, herbal formulations, and probiotics against aflatoxin-induced renal dysfunction, highlighting their mechanisms of action in both in vitro and in vivo studies. The natural products and dietary supplements discussed in this study alleviated aflatoxin-induced renal oxidative stress, inflammation, tissue damage, and markers of renal function, mostly in animal models. Therefore, the information provided in this review may improve the management of kidney disease associated with aflatoxin exposure and potentially aid in animal feed supplementation. However, future research is warranted to translate the outcomes of this study into clinical use in kidney patients.

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Section: Herbal Productmentioning

confidence: 99%

Section: Herbal Productmentioning

confidence: 99%

Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

Ofori-Attah,

Hashimoto,

Oki

et al. 2024

IJMS

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Effects of Separation and Purification Methods on Antioxidation, Hypoglycemic and DNA Protection Activity of Fenugreek Polysaccharide

Wang,

Feng,

Liang

et al. 2024

Chemistry & Biodiversity

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Six low molecular weight fenugreek polysaccharides (FP) were isolated and purified by ethanol stepwise precipitation (EFP‐20, EFP‐40, and EFP‐60) and DEAE‐52 cellulose column method (DFP‐0, DFP‐0.15, and DFP‐0.3), respectively. The effects of different separation and purification techniques on the preliminary properties and biological activities of fenugreek polysaccharides were compared. The results showed that the DEAE‐52 cellulose‐eluted fractions had a higher total sugar content and displayed a looser structure. The molecular weights of all six fractions were in the range of 4‐19 kDa, with significant changes in the ratio of galactose to mannose. All six fractions contained α‐D‐galactopyranose and β‐D‐mannopyranose structures. Activity tests showed that all six fractions possessed antioxidant, hypoglycemic and DNA‐protective activities. Among them, the DFP‐0 fraction showed the highest activity. Overall, different isolation and purification methods lead to changes in the properties and bioactivities of FP, which provides a theoretical basis for the development and application of FP in functional foods and drugs.

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Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi

Elgendy,

Nafie,

Nabil

et al. 2024

Nefrología

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Fenugreek (Trigonella foenum graecum L.) supplementation safeguards male mice from aflatoxin B1-induced liver and kidney damage

Cited by 5 publications

References 73 publications

Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

Effects of Separation and Purification Methods on Antioxidation, Hypoglycemic and DNA Protection Activity of Fenugreek Polysaccharide

Unveiling the antiurolithiatic potentiality of two benzene sulfonamide derivatives against ethylene glycol-induced renal calculi

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