2016
DOI: 10.1159/000440881
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Fermentative Cyclohexane Carboxylate Formation in <b><i>Syntrophus aciditrophicus</i></b>

Abstract: Short-chain fatty acids such as acetic, propionic, butyric or lactic acids are typical primary fermentation products in the anaerobic feeding chain. Fifteen years ago, a novel fermentation type was discovered in the obligately anaerobic Deltaproteobacterium Syntrophus aciditrophicus. During fermentative growth with crotonate and/or benzoate, acetate is formed in the oxidative branch and cyclohexane carboxylate in the reductive branch. In both cases cyclohexa-1,5-diene-1-carboxyl-CoA (Ch1,5CoA) is a central int… Show more

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Cited by 11 publications
(9 citation statements)
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“…The gene encoding the flavin-harboring HdrA subunit is not only found in methanogenic and methanotrophic archaea (Costa et al, 2013 ; Costa and Leigh, 2014 ; Lang et al, 2015 ; Browne et al, 2017 ; Yan et al, 2017 ) but also in sulfate reducing anaerobic bacteria and archaea (Grein et al, 2013 ; Meyer et al, 2013 , 2014 ; Price et al, 2014 ; Ramos et al, 2015 ; Otwell et al, 2016 ), sulfur-oxidizing bacteria (Mangold et al, 2011 ; Grein et al, 2013 ; Liu et al, 2013 ), strict anaerobes having the capacity to degrade aromatic compounds (Boll et al, 2014 , 2016 ), Syntrophorhabdus aromaticivorans (Nobu et al, 2015 ) and some acetogenic bacteria (Mock et al, 2014 ).…”
Section: Finding Of 10 Other Electron-bifurcating Flavoenzyme Complexmentioning
confidence: 99%
“…The gene encoding the flavin-harboring HdrA subunit is not only found in methanogenic and methanotrophic archaea (Costa et al, 2013 ; Costa and Leigh, 2014 ; Lang et al, 2015 ; Browne et al, 2017 ; Yan et al, 2017 ) but also in sulfate reducing anaerobic bacteria and archaea (Grein et al, 2013 ; Meyer et al, 2013 , 2014 ; Price et al, 2014 ; Ramos et al, 2015 ; Otwell et al, 2016 ), sulfur-oxidizing bacteria (Mangold et al, 2011 ; Grein et al, 2013 ; Liu et al, 2013 ), strict anaerobes having the capacity to degrade aromatic compounds (Boll et al, 2014 , 2016 ), Syntrophorhabdus aromaticivorans (Nobu et al, 2015 ) and some acetogenic bacteria (Mock et al, 2014 ).…”
Section: Finding Of 10 Other Electron-bifurcating Flavoenzyme Complexmentioning
confidence: 99%
“…The enzymology involved in fermentative formation of cyclohexanecarboxylate via cyclohexa-1,5-diene-1-carboxyl-CoA (Ch1,5CoA) from benzoate by the obligately anaerobic Syntrophus aciditrophicus is summarized by Boll et al [2016b]. During growth with benzoate, S. aciditrophicus employs the class II BCR for reductive dearomatization of benzoyl-CoA to Ch1,5CoA and its subsequent conversion by modified β-oxidation reactions to 3-hydroxypimelyl-CoA.…”
Section: Fermentative Formation Of Cyclohexanecarboxylatementioning
confidence: 99%
“…Stable isotope probing (SIP) has matured into a powerful and widely used approach to assess metabolic activities Boll et al [2016b].…”
Section: Stable Isotope Probingmentioning
confidence: 99%
“…To investigate the link between the oxidative and reductive branches during axenic growth with an unsaturated scFA, we opted for crotonate degradation in Syntrophus aciditrophicus as the model system. The fermentation balances and the intermediates of this pathway have been elucidated previously in this organism ( 26 , 27 ). Further, it can be grown easily with crotonate in the 200-L-scale in the absence of a methanogen yielding ≈200 g of wet cell mass within 2 weeks ( 17 ).…”
Section: Resultsmentioning
confidence: 83%