2019
DOI: 10.1002/fsn3.1200
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Fermented black radish (Raphanus sativus L. var. niger) attenuates methionine and choline deficient diet‐induced nonalcoholic fatty liver disease in mice

Abstract: As one of the wide‐ranging form of chronic liver disease, there are only limited therapeutic options for nonalcoholic fatty liver disease (NAFLD). We evaluated whether fermented black radish (Raphanus sativus L. var. niger; FBR) ameliorates lipid accumulation, inflammation, and hepatic fibrosis, which are characteristics of the pathogenesis of NAFLD. Fermented black radish treatment reduced lipid accumulation in 3T3‐L1 adipocytes, which appeared to be associated with the downregulation of adipogenic transcript… Show more

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Cited by 11 publications
(3 citation statements)
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“…Thus, fermented Spanish black radish had a hepatoprotective effect in CCl4-induced rat liver injury [45]. In another paper from the same group it was shown that the administration of fermented black radish to mice challenged with methionine and choline deficient diet significantly attenuated the increase in serum enzymes associated with hepatic cell injury such as alanine aminotransferase and aspartate aminotransferase [46]. Liver fibrosis and inflammation were also mitigated by treatment with fermented black radish.…”
Section: B Detoxification Activitymentioning
confidence: 95%
“…Thus, fermented Spanish black radish had a hepatoprotective effect in CCl4-induced rat liver injury [45]. In another paper from the same group it was shown that the administration of fermented black radish to mice challenged with methionine and choline deficient diet significantly attenuated the increase in serum enzymes associated with hepatic cell injury such as alanine aminotransferase and aspartate aminotransferase [46]. Liver fibrosis and inflammation were also mitigated by treatment with fermented black radish.…”
Section: B Detoxification Activitymentioning
confidence: 95%
“…R. sativus -has a strong antioxidant effect -root tubers, as well as leaves and peel, which are often discarded, contain significant amounts of antioxidants and phenol (Chorol 2019). In the treatment of nonalcoholic fatty liver disease, R. sativus improves biochemical parameters and reduces liver fibrosis (Ahn et al 2019).…”
Section: Brassicaceae Familymentioning
confidence: 99%
“…Niger) has been used since ancient times for the treatment of different diseases such as liver disorders [39]. Some recent studies indicate that it has hepatoprotective effects on CCL4-induced lesions [40]. It has also been found to have effects on high-fat diets by improving scavenging activity, as well as protecting the mucous membrane against lipid peroxidation [10].…”
Section: Hepatoprotective Plantsmentioning
confidence: 99%