Fermented Black Turmeric Designed by Lactobacillus Rearranged Leukocyte Subsets and Anti-Oxidative Activity

Watanabe, Yousuke; Yamaguchi, Nobuo; Horiuch, Isao; Murayama, Tsugia

doi:10.4236/oji.2015.53016

Cited by 3 publications

(3 citation statements)

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“…Fragmented Mechanism of innate and adaptive immunity regulation of natural medicines fermented by lactic acid bacteria. Zhu et al 10.3389/fmicb.2022.1073922 Frontiers in Microbiology frontiersin.org polysaccharide molecules produced by LAB-fermentation are shown to activate complement through the alternative pathway and regulate immune responses (Watanabe et al, 2015;Mastuba et al, 2017;Chen et al, 2022).…”

Section: The Complement Systemmentioning

confidence: 99%

“…The complement components, factors B, D, and P, help to induce a cascade of enzyme-catalyzed complement reaction pathways that lead to the production of C3 invertase and C5 invertase, the formation of membrane attack complex (MAC) and the destruction of target cells ( Gupta and Tripathy, 2020 ). Fragmented polysaccharide molecules produced by LAB-fermentation are shown to activate complement through the alternative pathway and regulate immune responses ( Watanabe et al, 2015 ; Mastuba et al, 2017 ; Chen et al, 2022 ).…”

Section: Immunoregulatory Mechanism Of Lactic Acid Bacteria-fermented...mentioning

confidence: 99%

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New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

Zhu

Yu²,

Du³

2022

Front. Microbiol.

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The COVID-19 pandemic has brought more attention to the immune system, the body’s defense against infectious diseases. The immunomodulatory ability of traditional herbal medicine has been confirmed through clinical trial research, and has obvious advantages over prescription drugs due to its high number of potential targets and low toxicity. The active compounds of herbal drugs primarily include polysaccharides, saponins, flavonoids, and phenolics and can be modified to produce new active compounds after lactic acid bacteria (LAB) fermentation. LAB, primary source of probiotics, can produce additional immunomodulatory metabolites such as exopolysaccharides, short-chain fatty acids, and bacteriocins. Moreover, several compounds from herbal medicines can promote the growth and production of LAB-based immune active metabolites. Thus, LAB-mediated fermentation of herbal medicines has become a novel strategy for regulating human immune responses. The current review discusses the immunomodulatory properties and active compounds of LAB fermented herbal drugs, the interaction between LAB and herbal medicines, and changes in immunoregulatory components that occur during fermentation. This study also discusses the mechanisms by which LAB-fermented herbal medicines regulate the immune response, including activation of the innate or adaptive immune system and the maintenance of intestinal immune homeostasis.

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Section: The Complement Systemmentioning

confidence: 99%

Section: Immunoregulatory Mechanism Of Lactic Acid Bacteria-fermented...mentioning

confidence: 99%

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

Zhu

Yu²,

Du³

2022

Front. Microbiol.

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“…These observations include the presence of receptors on lymphocytes for various complement proteins, including C3 split products and Factor H, affecting B-and T cell function. This is an important area for future research [73,74].…”

Section: Pathways Of Complement Activation and Complement Proteinsmentioning

confidence: 99%

A Constitution Dependent QOL Assessment

Yamaguchi¹

2017

J Tradi Med Clin Natur

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According to the reports from Ministry of Health in each country, the average life spans were expanded over the past century. This trend is expected to be extended further in the future and at the same time continuous efforts should be made. That indicates that the quantitative objective, as one of the objectives people have aimed at since ancient times to attain the perpetual youth and longevity, are almost achieved in this way. However, as the next objective, it is necessary for us to be concerned about improving the more advanced quality of life.In an effort of improving the quality of life, other than the western medicine, we have attempted to bring many traditional medical practices, including the Oriental medicine, from various parts of the world into the medical field as alternative medicine. Judging both positive and negative aspects by the evaluation standard of the Western medicine, we try to obtain numerical values of QOL, and after that, set a numerical target for improvement of QOL. Some methods of alternative medicine taken in this review are acupuncture moxibustion, Chinese medicine and other traditional medicine. Above all, WHO suggests selecting the suzerain nation of acupuncture moxibustion, which has been developed in the Oriental countries and realized as a specialized cure, by raising good & bad points and ascertaining which nation advocating the best modeling method could be. At the moment for evaluating CAM, for example, what kind of methods is/are suitable for evaluating each CAM. We have been trying to propose the peripheral leukocyte is one of the best ways for evaluating CAM. Our trials are hot spring hydro therapy, acupuncture and moxibution, light exercise and undle heating. In these evaluations, we found the common results from leukocyte effects which exhibited strong correlation for the regulation. The contents are the result from the data showing the much in number tend to downly regulate, on the other hand lower number one is up-regulated. This kind of regulation showed within a 24 hrs, for the leukocyte subsets, granulocyte and lymphocyte are changed under circadian rhythm. So for purpose of evaluating leukocyte deviation, we set the point for evaluation at the same-time zone from the first set of evaluation. Under these condition, we got a same results reproductively that the whole number of leukocyte, and its subset, granulocyte and lymphocyte also regulated within a 24 hrs. This kind of phenomenon is the case that we confirm a lot of kind of CAM and repetition. However, the life span of leukocyte are at lease 3-4 days and no such a drastic apoptosis was induced such a stimulation. For the purpose of scientific explanation, we proposed that the emotional hormone are concern this change of leukocytes population. For the results of this hypothesis, there were reasonable change were seen in the peripheral blood about emotional hormone, adrenaline and dopamine. Other hormone concern thyroid grand was not changed significantly. In this review, I plan to collect evidence and...

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Fermented Herbal Decoction Selectively Targeting Human Cancer Cell Line and Human Pathogenic Microorganism

Yamaguchi¹,

Amat²,

Okamoto³

et al. 2018

OJRA

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Introduction: Prolonged immuno-suppressed status promised to induce internal growth of malignant cell and infectious agent, yet, only a small part of affected individuals seek medical attention or berried by commercially over-flowed fake information. Several studies have described complementary and alternative medicine as effective strategies for improving anti-infectious agent including malignant cell. The purpose of this study was to investigate the effect of a fermented herbal decoction (FHD) both in vitro and in vivo to malignant cells and microorganism by regulating leukocyte subset proportioning FHD as dietary material. Methods: In this approach of alternative study, selective anti-cancer effect by fermented decoction was tried to show first in vitro system both, cancer cell and virus strain. The fermented herbal decoction consisting of 80 sorts of herbs and fruits. The selective toxicity was set up and then for immunological factors in animal and human. The most important factor is to reduce side effect for a normal cell. Results: First, FHD was proved as safe by animal test. FHD regulated also the proportion of granulocyte and lymphocyte ratio both animal and human. In vitro culture showed selective toxicity by FHD against human melanoma and leukemia cell line but reduced toxicity was showed by normal cell line. As for the anti-virus activity, anti-virus effect was tested on the feeder layer of human fibroblast cell, after 9 days of culture. Second, FHD inhibits colon cancer growth in 3-methylholanthrene induced cancer in rat. Conclusion: The present results suggest that our fermented herbal decoction showed selective anti-cancer activities and anti-virus activities, together with the regulative effect on the immune system.

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Fermented Black Turmeric Designed by Lactobacillus Rearranged Leukocyte Subsets and Anti-Oxidative Activity

Cited by 3 publications

References 15 publications

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

New insights into immunomodulatory properties of lactic acid bacteria fermented herbal medicines

A Constitution Dependent QOL Assessment

Fermented Herbal Decoction Selectively Targeting Human Cancer Cell Line and Human Pathogenic Microorganism

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