Fermented Broth in Tyrosinase- and Melanogenesis Inhibition

Chan, Chin-Feng; Huang, Ching-Cheng; Lee, Ming-Yuan; Lin, Yung‐Sheng

doi:10.3390/molecules190913122

Cited by 55 publications

(52 citation statements)

References 95 publications

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“…The mitogen‐activated protein kinase (MAPK) signalling pathway (including ERK, P38 and JNK) has been shown to play a key role in melanogenesis by affecting tyrosinase . It has been found that activation of the MAPK signalling pathway can upregulate the expression of TYR, TYRP1 and TYRP2 to promote melanogenesis .…”

Section: Introductionmentioning

confidence: 99%

Downregulation of TUG1 promotes melanogenesis and UVB‐induced melanogenesis

Chen

et al. 2019

Experimental Dermatology

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Studies have revealed that taurine upregulated gene 1 (TUG1), an important member of the long non‐coding RNA family, is involved in the regulation of cell growth, tumorigenesis and invasion, insulin secretion and so on. However, its role in melanogenesis has not been explored. This study attempts to explore the effects of TUG1 on melanogenesis and its regulatory mechanisms. We evaluated the expression changes in melanogenesis‐related genes and detected phosphorylation levels of ERK, JNK and P38 in TUG1 downregulated melanocytes. After exposure of melanocytes to UVB irradiation, the expression of TUG1 and melanogenesis‐related genes was detected. We found that the expression of tyrosinase (TYR), tyrosine‐related protein 1 (TYRP1) and tyrosine‐related protein 2 (TYRP2) was upregulated and that the phosphorylation level of ERK was downregulated by downregulating TUG1. Inhibition of TUG1 could further upregulate the expression of UVB‐induced melanogenesis‐related genes. In conclusion, TUG1 negatively regulates melanocyte melanogenesis via the ERK pathway and plays a negative role in UVB‐induced melanogenesis.

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Section: Introductionmentioning

confidence: 99%

Downregulation of TUG1 promotes melanogenesis and UVB‐induced melanogenesis

Chen

et al. 2019

Experimental Dermatology

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“…The MITF gene itself is a target of cAMP signaling induced by α-MSH, and predominantly regulates tyrosinase and TRP-1 protein expression [35,36,37]. In the cAMP-dependent signaling pathway, the dual phosphorylation of the cAMP response element binding protein (CREB), mediated by the kinase activities of ribosomal S6 kinase (RSK) and PKA, has been found to activate MITF transcription [38,39]. Furthermore, it has been reported that suppression of the cAMP-dependent signaling pathway causes MITF degradation in α-MSH-stimulated melanoma cells [40].…”

Section: Resultsmentioning

confidence: 99%

“…The phosphorylation of Raf-1 activates (phosphorylates) a series of mitogen-activated protein kinases (MEKs), extracellular signal-regulated kinases (ERKs), RSKs, and CREB in the mitogen-activated protein kinase (MAPK) cascade [41]. In addition, the MAPK family proteins including ERK, p38, and c-Jun N-terminal kinase (JNK) are also known to play crucial roles in melanogenesis [39]. The phosphorylation of p38 induces MITF expression, whereas the phosphorylation of ERK and JNK downregulate melanin synthesis [39].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Kim

et al. 2016

IJMS

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Ganoderma lucidum, a species of the Basidiomycetes class, has been attracting international attention owing to its wide variety of biological activities and great potential as an ingredient in skin care cosmetics including “skin-whitening” products. However, there is little information available on its inhibitory effect against tyrosinase activity. Therefore, the objectives of this study were to investigate the chemical composition of G. lucidum and its inhibitory effects on melanogenesis. We isolated the active compound from G. lucidum using ethanol extraction and ethyl acetate fractionation. In addition, we assayed its inhibitory effects on tyrosinase activity and melanin biosynthesis in B16F10 melanoma cells. In this study, we identified a bioactive compound, ganodermanondiol, which inhibits the activity and expression of cellular tyrosinase and the expression of tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF), thereby decreasing melanin production. Furthermore, ganodermanondiol also affected the mitogen-activated protein kinase (MAPK) cascade and cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, which are involved in the melanogenesis of B16F10 melanoma cells. The finding that ganodermanondiol from G. lucidum exerts an inhibitory effect on tyrosinase will contribute to the use of this mushroom in the preparation of skin care products in the future.

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“…There is increasing interest in the use of plant natural products for inhibition of melanogenesis [17,18]. However, little is known about the effect of proso millet on tyrosinase activity.…”

Section: Introductionmentioning

confidence: 99%

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

Huang

Chen

Lin

et al. 2018

Journal of Chemistry

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Proso millet (Panicum miliaceum) is rich in nutritive components and is widely used as a human food, feed and forage for animals, and fuel. This study investigated the effect of a proso millet extract on the inhibition of tyrosinase, a key enzyme in melanogenesis. High performance liquid chromatography analysis indicated that the proso millet extract contained phenolic tyrosinase inhibitors, such as syringic acid, -coumaric acid, and ferulic acid. The extract had an IC 50 for inhibition of tyrosinase activity of 14.02 mg/mL. A Lineweaver-Burk double reciprocal plot showed that the proso millet extract functioned as a mixed competitive and noncompetitive inhibitor. Proso millet has potential as a tyrosinase inhibitor that may have applications in the cosmetics industry.

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Fermented Broth in Tyrosinase- and Melanogenesis Inhibition

Cited by 55 publications

References 95 publications

Downregulation of TUG1 promotes melanogenesis and UVB‐induced melanogenesis

Downregulation of TUG1 promotes melanogenesis and UVB‐induced melanogenesis

Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum

Kinetics Investigation on Mushroom Tyrosinase Inhibition of Proso Millet

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