Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice

Ofosu, Fred Kwame; Elahi, Fazle; Daliri, Eric Banan‐Mwine; Aloo, Simon Okomo; Chelliah, Ramachandran; Han, Sang‐Ik; Oh, Deog‐Hwan

doi:10.1016/j.jff.2023.105666

Cited by 12 publications

(1 citation statement)

References 39 publications

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“…Moreover, it has been elucidated that Alloprevotella contributes to the favorable outcomes observed in nutritional interventions targeting metabolic parameters associated with obesity [45]. Parabacteroides were also positively correlated with the production of SCFAs and have beneficial effects in reducing weight gain, hyperglycemia, and inflammation risk, maintaining intestinal barrier integrity, and improving insulin resistance and antioxidant enzyme activity [46]. These results indicate that SH-P treatment alleviates diabetic symptoms by improving the structure and composition of the gut microbiota and selectively restoring the abundance of probiotics while possibly also suppressing the growth of potential pathogens.…”

Section: Discussionmentioning

confidence: 99%

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice

Ni,

Li,

Qian

et al. 2023

Molecules

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Gut microbiota dysbiosis has been reported as a risk factor in the development of type 2 diabetes mellitus (T2DM). Polysaccharides from Phellinus igniarius (P. igniarius) possess various properties that help manage metabolic diseases; however, their underlying mechanism of action remains unclear. Therefore, in this study, we aimed to evaluate the effect of P. igniarius polysaccharides (SH-P) on improving hyperglycemia in mice with T2DM and clarified its association with the modulation of gut microbiota and their metabolites using 16S rDNA sequencing and liquid chromatography–mass spectrometry. Fecal microbiota transplantation (FMT) was used to verify the therapeutic effects of microbial remodeling. SH-P supplementation alleviated hyperglycemia symptoms in T2DM mice, ameliorated gut dysbiosis, and significantly increased the abundance of Lactobacillus in the gut. Pathway enrichment analysis indicated that SH-P treatment altered metabolic pathways associated with the occurrence and development of diabetes. Spearman’s correlation analysis revealed that changes in the dominant bacterial genera were significantly correlated with metabolite levels closely associated with hyperglycemia. Additionally, FMT significantly improved insulin sensitivity and antioxidative capacity and reduced inflammation and tissue injuries, indicating improved glucose homeostasis. These results indicate that the ameliorative effects of SH-P on hyperglycemia are associated with the modulation of gut microbiota composition and its metabolites.

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Section: Discussionmentioning

confidence: 99%

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice

Ni,

Li,

Qian

et al. 2023

Molecules

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MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice

Bajaj,

Choudhary,

Singh

et al. 2024

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Metabolic disorders such as Type 2 diabetes mellitus (T2DM) imposes a significant global health burden. Plant‐derived exosome like nanoparticles (P‐ELNs) have emerged as a promising therapeutic alternate for various diseases. Present data demonstrates that treatment with Ginger‐derived exosome like nanoparticles (G‐ELNs) enhance insulin dependent glucose uptake, downregulate gluconeogenesis and oxidative stress in insulin resistant HepG2 cells. Furthermore, oral administration of G‐ELNs in T2DM mice decreases fasting blood glucose levels and improves glucose tolerance as effectively as metformin. These improvements are attributed to the enhanced phosphorylation of Protein kinase B (Akt‐2), the phosphatidylinositol 3‐kinase at serine 474 which consequently leads to increase in hepatic insulin sensitivity, improvement in glucose homeostasis and decrease in ectopic fat deposition. Oral administration of G‐ELNs also exerts protective effect on Streptozotocin (STZ)‐induced pancreatic β‐cells damage, contributing to systemic amelioration of T2DM. Further, as per computational tools, miRNAs present in G‐ELNs modulate the phosphatidylinositol 3‐kinase (PI3K)/Akt‐2 pathway and exhibit strong interactions with various target mRNAs responsible for hepatic gluconeogenesis, ectopic fat deposition and oxidative stress. Furthermore, synthetic mimic of G‐ELNs miRNA effectively downregulates its target mRNA in insulin resistant HepG2 cells. Overall, the results indicate that the miRNAs present in G‐ELNs target hepatic metabolism thus, exerting therapeutic effects in T2DM.

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The dietary supplementation of Sargassum fusiforme can effectively alleviate high-fat diet induced metabolic abnormalities

Bai,

Fu,

Chen

et al. 2024

Algal Research

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Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice

Cited by 12 publications

References 39 publications

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice

MicroRNAs Dependent G‐ELNs Based Intervention Improves Glucose and Fatty Acid Metabolism While Protecting Pancreatic β‐Cells in Type 2 Diabetic Mice

The dietary supplementation of Sargassum fusiforme can effectively alleviate high-fat diet induced metabolic abnormalities

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