Fermented Soybean Paste Attenuates Biogenic Amine-Induced Liver Damage in Obese Mice

Abstract

Biogenic amines are cellular components produced by the decarboxylation of amino acids; however, excessive biogenic amine production causes adverse health problems. The relationship between hepatic damage and biogenic amine levels in nonalcoholic fatty liver disease (NAFLD) remains unclear. In this study, mice were fed a high-fat diet (HFD) for 10 weeks to induce obesity, presenting early-stage of NAFLD. We administered histamine (20 mg/kg) + tyramine (100 mg/kg) via oral gavage for 6 days to mice with HFD-induced early-stage NAFLD. The results showed that combined histamine and tyramine administration increased cleaved PARP-1 and IL-1β in the liver, as well as MAO-A, total MAO, CRP, and AST/ALT levels. In contrast, the survival rate decreased in HFD-induced NAFLD mice. Treatment with manufactured or traditional fermented soybean paste decreased biogenically elevated hepatic cleaved PARP-1 and IL-1β expression and blood plasma MAO-A, CRP, and AST/ALT levels in HFD-induced NAFLD mice. Additionally, the biogenic amine-induced reduction in survival rate was alleviated by fermented soybean paste in HFD-induced NAFLD mice. These results show that biogenic amine-induced liver damage can be exacerbated by obesity and may adversely affect life conservation. However, fermented soybean paste can reduce biogenic amine-induced liver damage in NAFLD mice. These results suggest a beneficial effect of fermented soybean paste on biogenic amine-induced liver damage and provide a new research perspective on the relationship between biogenic amines and obesity.

Oxymatrine Alleviates High-Fat-High-Fructose-Induced Fatty Liver in Rats: Understanding the Molecular Mechanism Through an Untargeted Metabonomics Study

“… 35 Increased levels of its metabolite histamine lead to elevated levels of PARP-1 and IL-1β, as well as MAO-A, total MAO, CRP, and AST/ALT, causing liver injury. 36 In addition, histamine may regulate metabolic and inflammatory processes in other organs targeted by metabolic syndrome. Two potential mechanisms associated with histamine receptors may attenuate liver injury during the initial and progressive stages of NAFLD in a manner involving the regulation of cholesterol and bile acid metabolism.…”

Cultivated Enterococcus faecium B6 from children with obesity promotes nonalcoholic fatty liver disease by the bioactive metabolite tyramine

“… 31 In addition, a preclinical study indicated that tyramine might induce liver damage and adversely affect life conservation. 32 However, the causal relationship between specific species/strains and their derived metabolites in NAFLD pathogenesis has not been fully elucidated, especially in children.…”

Comparative Analysis of the Effect of Dietary Supplementation with Fermented and Water-Extracted Leaf Extracts of Eucommia ulmoides on Egg Production and Egg Nutrition

“…Therefore, probiotic fermentation might be an ideal approach to improve the palatability of Chinese medicine plants. However, apart from these advantages, the detrimental effects of probiotic fermentation should also be considered, e.g., the generation of biogenic amines, which cause liver damage, block DNA replication, and disturb biosynthesis [21,22]. Given this point, the safety of the fermentation extract should be explored to ensure the healthy farming of poultry.…”