Fermented Vegetables as a Potential Treatment for Irritable Bowel Syndrome

Garnås, Eirik

doi:10.1016/j.cdnut.2023.100039

Cited by 4 publications

(1 citation statement)

References 88 publications

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“…Fermented vegetables contain a wide variety of bacteria that are involved in digestion, antipathogenic, and immunomodulatory activities [ 136 , 137 ]. The natural bacteria found on vegetable surfaces serve as starter cultures for fermentation.…”

Section: Plant and Food Compounds With Antifungal Propertiesmentioning

confidence: 99%

Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection

Jawhara

2023

Microorganisms

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Western diets are rapidly spreading due to globalization, causing an increase in obesity and diseases of civilization. These Western diets are associated with changes in the gut microbiota related to intestinal inflammation. This review discusses the adverse effects of Western diets, which are high in fat and sugar and low in vegetable fiber, on the gut microbiota. This leads to gut dysbiosis and overgrowth of Candida albicans, which is a major cause of fungal infection worldwide. In addition to an unhealthy Western diet, other factors related to disease development and gut dysbiosis include smoking, excessive alcohol consumption, lack of physical activity, prolonged use of antibiotics, and chronic psychological stress. This review suggests that a diversified diet containing vegetable fiber, omega-3 polyunsaturated fatty acids, vitamins D and E, as well as micronutrients associated with probiotic or prebiotic supplements can improve the biodiversity of the microbiota, lead to short-chain fatty acid production, and reduce the abundance of fungal species in the gut. The review also discusses a variety of foods and plants that are effective against fungal overgrowth and gut dysbiosis in traditional medicine. Overall, healthy diets and lifestyle factors contribute to human well-being and increase the biodiversity of the gut microbiota, which positively modulates the brain and central nervous system.

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Section: Plant and Food Compounds With Antifungal Propertiesmentioning

confidence: 99%

Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection

Jawhara

2023

Microorganisms

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Sauerkraut and fermented cabbage juices

Rodrigues,

da Silva Valigura,

de Cassia Campos Pena

et al. 2025

Unconventional Functional Fermented Beverages

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The fermented cabbage metabolome and its protection against cytokine-induced intestinal barrier disruption of Caco-2 monolayers

Wei,

Marco

2024

Preprint

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Fermented vegetables, such as fermented cabbage (sauerkraut), have garnered growing interest for their associations with a myriad of health benefits. However, the mechanistic details underlying the outcomes of consuming these foods require further investigation. This study examined the capacity of soluble metabolites in laboratory-scale and commercial fermented cabbage to protect against disruption of polarized Caco-2 monolayers by IFN-γ and TNF-α. Laboratory-scale ferments (LSF) were prepared with and without the addition of Lactiplantibacillus plantarum NCIMB8826R (LP8826R) and sampled after 7- and 14-days of incubation. Trans-epithelial electrical resistance (TER) and paracellular permeability to fluorescein isothiocyanate-dextran (FITC) revealed that fermented cabbage, but not raw cabbage or brine, protected against cytokine-induced damage to the Caco-2 monolayers. Barrier-protective effects occurred despite increased IL-8 production following cytokine exposure. Metabolomic analyses performed using gas and liquid chromatography resulted in the identification of 149 and 333 metabolites, respectively. Significant differences were found between raw and fermented cabbage. LSF metabolomes changed over time and the profiles of LSF with LP8826R best resembled the commercial product. Overall, fermentation resulted in lower carbohydrate and increased lactic acid, lipid, amino acid derivative (including D-phenyl-lactate (D-PLA), indole-3-lactate (ILA), and γ-aminobutyric acid (GABA)), and phenolic compound concentrations. Lactate, D-PLA, and ILA tested individually and combined only partially protected against cytokine-induced TER reductions and increases in paracellular permeability of Caco-2 monolayers. The findings show that intestinal barrier-protective compounds are consistently enriched during cabbage fermentations, irrespective of scale or microbial additions, that may contribute to the health-promoting potential of these foods.

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Fermented Vegetables as a Potential Treatment for Irritable Bowel Syndrome

Cited by 4 publications

References 88 publications

Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection

Healthy Diet and Lifestyle Improve the Gut Microbiota and Help Combat Fungal Infection

Sauerkraut and fermented cabbage juices

The fermented cabbage metabolome and its protection against cytokine-induced intestinal barrier disruption of Caco-2 monolayers

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