Ferroferric oxide loaded near-infrared triggered photothermal microneedle patch for controlled drug release

Cui, Jiuyu; Huang, Jun; Yan, Yonggan; Chen, Wenqian; Wen, Jie; Wu, Xunwei; Liu, Ji‐Kai; Liu, Hanlian; Huang, Chuanzhen

doi:10.1016/j.jcis.2022.03.046

Cited by 25 publications

(9 citation statements)

References 48 publications

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“…Studies in the literature indicate that microneedles can penetrate the skin without breaking when their failure force exceeds 240 mN/needle. 28 With regard to the aforementioned observations, we consider that the drug-carrying bilayer microneedles that are cross-linked can effectively penetrate the skin and deliver medication.…”

Section: Hygroscopicity and In Vivo Dissolution Of Microneedlesmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

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Chronic pain emerges as a major global health issue, significantly impacting individuals' health and quality of life. In this study, we designed a bilayer microneedle loaded with lidocaine nanocomposites in the inner layer and adrenaline (Adr) in the outer layer (HCP MNs) for modulated sequential release to achieve prolonged local anesthesia. The obtained HCP MNs featured an intact structure with adequate mechanical strength for efficient skin penetration. The bilayer structure of MNs was evidenced by loading two fluorescent dyes in each layer. Furthermore, these HCP MNs were capable of inducing rapid as well as prolonged local anesthetic effects in guinea pigs. Hence, the bilayer MN coloaded with Adr and lidocaine nanocomposite serves as a promising transdermal delivery platform for chronic pain management.

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Section: Hygroscopicity and In Vivo Dissolution Of Microneedlesmentioning

confidence: 99%

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Xia,

Xu,

Luo

et al. 2024

ACS Appl. Bio Mater.

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“…9(f), Chuanzhen Huang et al proposed a photothermally responsive and temperature-sensitive Fe 3 O 4 -loaded MN patch (Fe 3 O 4 @MN) for controlled transdermal drug delivery. 90 Gelatin-polyethylene glycol hydrogel (Fe 3 O 4 -gp) and Fe 3 O 4 -gp microneedles (Fe 3 O 4 @MN) were prepared by simple polymerization of gelatin, Fe 3 O 4 nanoparticles and PEGDA monomer. Under near infrared (NIR) irradiation, the drug loaded on Fe 3 O 4 @MN was released rapidly, and the purpose of improving the drug release efficiency was achieved.…”

Section: Applications In the Medical Fieldmentioning

confidence: 99%

Recent advances of biosensors on microneedles

Ma,

Zhou,

Gao

2023

Anal. Methods

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“…Hydrogels are water-rich porous polymer materials that have been extensively utilized in multidisciplinary fields including pharmaceutical transportation, biosensors, and medicine. , Recently, hydrogels have been designed in various forms such as functional coatings, microspheres, microneedles, fibers, or biosensors to address different scenarios. Among them, hydrogel microspheres have been attracting considerable interest in drug and cell delivery due to their exceptional injectability and biocompatibility. , …”

Section: Introductionmentioning

confidence: 99%

Optimizing the Production of Hydrogel Microspheres Using Microfluidic Chips: The Influence of Surface Treatment on Droplet Formation Mechanism

Zhang,

Li,

Wei

et al. 2023

Langmuir

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Microfluidic chips have been widely applied in biology and medical research for stably generating uniform droplets that can be solidified into hydrogel microspheres. However, issues such as low microsphere yield, lengthy experimental processes, and susceptibility to environmental interference need to be addressed. In this work, a simple and effective method was developed to modify microfluidic chips at room temperature to improve the production performance of hydrogel microspheres. Numerical simulation-assisted experiments were conducted to comprehensively understand the effect of solution viscosity, hydrophilicity, and flow rate ratio on droplet formation during microsphere production. Chitosan was selected as the main component and combined with poly(ethylene glycol) diacrylate to prepare photocurable hydrogel microspheres as a demonstration. As a result, grafting fluoro-silane (FOTS) increased the contact angle of the channel from 90 to approximately 110°, which led to a 12.2% increase in droplet yield. Additionally, FOTS-modification attenuated the impact of the flow rate ratio on droplet yield by 19.1%. Alternatively, depositing dopamine decreased the channel’s contact angle from 90 to 60°, resulting in a 21.4% increase in particle size and enabling the chip to adjust droplet size over a wider range. Further study demonstrates that the obtained hydrogel microspheres can be modified with layers of aldehyde, which can potentially be used for controlled drug release. Overall, this study proposed a facile method for adjusting the yield and droplet size through surface treatment of microfluidic chips while also enhancing the understanding of the synergistic effects of multiple factors in microfluidics-based microsphere production.

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Ferroferric oxide loaded near-infrared triggered photothermal microneedle patch for controlled drug release

Cited by 25 publications

References 48 publications

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

A Bilayer Microneedle for Modulated Sequential Release of Adrenaline and Lidocaine for Prolonged Local Anesthesia

Recent advances of biosensors on microneedles

Optimizing the Production of Hydrogel Microspheres Using Microfluidic Chips: The Influence of Surface Treatment on Droplet Formation Mechanism

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