Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Pu, Feifei; Chen, Fengxia; Zhang, Zhicai; Shi, Deyao; Zhong, Botao; Lv, Xiao; Tucker, Andrew; Fan, Jiaming; Li, Alexander J.; Qin, Kevin; Hu, Daniel A.; Chen, Connie; Wang, Hao; He, Fang; Ni, N.; Huang, Linjuan; Liu, Qing; Wagstaff, William; Luu, Hue H.; Haydon, Rex C.; Shen, Le; He, Tong‐Chuan; Liu, Jianxiang; Shao, Zengwu

doi:10.1016/j.gendis.2020.11.019

Cited by 35 publications

(22 citation statements)

References 125 publications

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“…Considering MeO-MBM's efficacy in vivo in improving the skin barrier function and downregulation of proteins in the context of inflammation, the question arose whether MeO-MBM is a classical antioxidative molecule or whether the functionality is attributed to reduction of ROS and reactive nitrogen species (RNS) by downregulation of enzymes keeping the reactive species machinery active, e.g., superoxide dismutase 1 and 2 (SOD 1 and 2), which are known to modulate the free iron content in living cells upon cellular stress. Free iron is toxic to mammalian cells and typically binds to ferritin to avoid ferroptosis-a subform of apoptosis [34,35]. Therefore, a final experiment was conducted to determine the effect of MeO-MBM after UV-induced stress on the activation of ferritin in ex-vivo human explants.…”

Section: Resultsmentioning

confidence: 99%

Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Termer

Jaeger

Carola

et al. 2021

Dermatol Ther (Heidelb)

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Section: Resultsmentioning

confidence: 99%

Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Termer

Jaeger

Carola

et al. 2021

Dermatol Ther (Heidelb)

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“…Ferroptosis is yet another form of programmed cell death that manifests itself similarly to necrosis and is induced by oxidative stress associated with disturbances in iron metabolism [ 65 ]. As a result of exposure to both forms of PM, the term ferroptosis was significantly enriched, with LAp120 having a slightly greater effect than NIST1648a in contrast to the other forms of cell death discussed above.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Changes Induced by Exposure of RAW 264.7 Macrophages to Particulate Matter of Air Pollution: The Role of Endotoxins

et al. 2022

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Despite the variable chemical and physical characteristics of particulate air pollutants, inflammation and oxidative stress have been identified as common mechanisms for cell damage and negative health influences. These effects are produced by organic components, especially by endotoxins. This study analyzed the gene expression profile after exposure of RAW 264.7 cells to the standard particulate matter (PM) material, NIST1648a, and PM with a reduced organic matter content, LAp120, in comparison to the effects of lipopolysaccharide (LPS). The selected parameters of cell viability, cell cycle progression, and metabolic and inflammatory activity were also investigated. Both forms of PM negatively influenced the parameters of cell activity. These results were generally reflected in the gene expression profile. Only NIST1648a, excluding LAp120, contained endotoxins and showed small but statistically significant pro-inflammatory activity. However, the gene expression profiling revealed strong pro-inflammatory cell activation induced by NIST1648a that was close to the effects of LPS. Changes in gene expression triggered by LAp120 were relatively small. The observed differences in the effects of NIST1648a and LAp120 were related to the content of organic matter in which bacterial endotoxins play an important role. However, other organic compounds and their interactions with other PM components also appear to be of significant importance.

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“…Intracellular iron is also involved in oxygen transport, energy metabolism, and other biological processes. Large amounts of iron promote the proliferation and metastasis of cancer cells (Pu et al, 2022). However, excessive iron concentrations produce excessive reactive oxygen species (ROS), resulting in ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

Sun

2022

Front. Genet.

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Endometriosis (EMs), one of the most common gynecological diseases, seriously affects the health and wellness of women; however, the underlying pathogenesis remains unclear. This study focused on dysregulated genes and their predicted transcription factors (TFs) and miRNAs, which may provide ideas for further mechanistic research. The microarray expression dataset GSE58178, which included six ovarian endometriosis (OE) samples and six control samples, was downloaded from the Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs). Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to study the cellular and organism-level functions of DEGs. The protein-protein interaction (PPI) network was built and visualized using Cytoscape, and modules and hub genes were explored using various algorithms. Furthermore, we predicted miRNAs and TFs of hub genes using online databases, and constructed the TF-miRNA-hub gene network. There were 124 upregulated genes and 66 downregulated genes in EMs tissues. GO enrichment analysis showed that DEGs were concentrated in reproductive structure development and collagen-containing extracellular matrix, while KEGG pathway analysis showed that glycolysis/gluconeogenesis and central carbon metabolism in cancer require further exploration. Subsequently, HIF1A, LDHA, PGK1, TFRC, and CD9 were identified as hub genes, 22 miRNAs and 34 TFs were predicted to be upstream regulators of hub genes, and these molecules were pooled together. In addition, we found three key feedback loops in the network, MYC-miR-34a-5p-LDHA, YY1-miR-155-5p-HIF1A, and RELA-miR-93-5p-HIF1A, which may be closely related to OE development. Taken together, our study structured a TF-miRNA-hub gene network to decipher the molecular mechanism of OE, which may provide novel insights for clinical diagnosis and treatment.

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Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer

Cited by 35 publications

References 125 publications

Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Methoxy-Monobenzoylmethane Protects Skin from UV-Induced Damages in a Randomized, Placebo Controlled, Double-Blinded Human In Vivo Study and Prevents Signs of Inflammation While Improving the Skin Barrier

Gene Expression Changes Induced by Exposure of RAW 264.7 Macrophages to Particulate Matter of Air Pollution: The Role of Endotoxins

Identification of functional TF-miRNA-hub gene regulatory network associated with ovarian endometriosis

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