Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy

Wang, Ziqian; LI, YAQI; WANG, DONGYANG; Shen, Yingqiang

doi:10.32604/biocell.2022.018530

Cited by 3 publications

(3 citation statements)

References 98 publications

(105 reference statements)

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“…The regulation of ferroptosis is focused mainly on the regulation of lipid peroxidation level in cells. Although the mechanism and the metabolic pathway of ferroptosis are still poorly understood, multiple types of inhibitors and inducers have been reported in practice [10]. This review intends to summarize the type and mechanism of commonly used and newly discovered ferroptosis inducers and inhibitors based on important metabolic pathways, and discuss their application in scientific research and disease treatment.…”

Section: Introductionmentioning

confidence: 99%

Recent progress in ferroptosis: inducers and inhibitors

Guo

2022

Cell Death Discov.

125

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Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities in pursuit to reveal the mechanism and key targets of ferroptosis because ferroptosis is closely related to the pathophysiological processes of many diseases. Recent studies have shown some key targets, such as glutathione peroxidase 4 (GPX4) and System Xc−, and several inducers and inhibitors have been developed to regulate these key targets. With the emergence of new ferroptosis targets, studies on inducers and inhibitors have made new developments. The selection and use of inducers and inhibitors are very important for related work. This paper briefly introduces important regulatory targets in the ferroptosis metabolic pathway, lists and categorizes commonly used and recently developed inducers and inhibitors, and discusses their medical application. The paper ends of with potential future research direction for ferroptosis.

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Section: Introductionmentioning

confidence: 99%

Recent progress in ferroptosis: inducers and inhibitors

Guo

2022

Cell Death Discov.

125

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“…It has also been found that phosphorylated HSPB1 induced by erastin can block cytoskeleton-mediated iron uptake and subsequent lipid peroxidation under ferroptosis ( Figure 2F ) ( 87 ). Previous studies have confirmed that the expression of HSBP1 can be upregulated with the loss of FANCD2 which is the central protein of the Fanconi anemia (FA) pathway ( 88 ). In addition, loss of FANCD2 is also closely related to increased gene expression for iron uptake (such as transferrin and transferrin receptor) and decreased gene expression for iron storage (such as FTH) and iron export (such as hepcidin antimicrobial peptide) in ferroptosis ( 89 ).…”

Section: The Role Of Ferroptosis In Autophagymentioning

confidence: 96%

The crosslinks between ferroptosis and autophagy in asthma

Tang

Qin

et al. 2023

Front. Immunol.

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Autophagy is an evolutionarily conserved cellular process capable of degrading various biological molecules and organelles via the lysosomal pathway. Ferroptosis is a type of oxidative stress-dependent regulated cell death associated with the iron accumulation and lipid peroxidation. The crosslinks between ferroptosis and autophagy have been focused on since the dependence of ferroptosis on autophagy was discovered. Although the research and theories on the relationship between autophagy and ferroptosis remain scattered and fragmented, the crosslinks between these two forms of regulated cell death are closely related to the treatment of various diseases. Thereof, asthma as a chronic inflammatory disease has a tight connection with the occurrence of ferroptosis and autophagy since the crosslinked signal pathways may be the crucial regulators or exactly regulated by cells and secretion in the immune system. In addition, non-immune cells associated with asthma are also closely related to autophagy and ferroptosis. Further studies of cross-linking asthma inflammation with crosslinked signaling pathways may provide us with several key molecules that regulate asthma through specific regulators. The crosslinks between autophagy and ferroptosis provide us with a new perspective to interpret and understand the manifestations of asthma, potential drug discovery targets, and new therapeutic options to effectively intervene in the imbalance caused by abnormal inflammation in asthma. Herein, we introduce the main molecular mechanisms of ferroptosis, autophagy, and asthma, describe the role of crosslinks between ferroptosis and autophagy in asthma based on their common regulatory cells or molecules, and discuss potential drug discovery targets and therapeutic applications in the context of immunomodulatory and symptom alleviation.

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“…Furthermore, antitumor activity was found in a variety of animal models ( 9 ). Interestingly, PL has very little toxicity to human normal cells as a natural herbal medicine ( 11 ). There are many ways for PL to kill tumor cells, including increasing the level of intracellular reactive oxygen species [ROS, a group of molecules derived from molecular oxygen, mainly including hydrogen peroxide (H 2 O 2 ), singlet oxygen (1O 2 ), superoxide anion (O 2 •– ) and hydroxyl radicals (•OH)], cell cycle arrest and regulating autophagy.…”

Section: Introductionmentioning

confidence: 99%

Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity

Wang¹,

Li²,

Wang³

et al. 2023

Transl Cancer Res

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Background: As a new form of cell death, ferroptosis has been shown to have inhibitory effects on a variety of tumor cells except oral squamous cell carcinoma (OSCC). There were few investigations on the effects and molecular mechanisms of piperlongumine (PL, a ferroptosis inducer) and CB-839 (a GLS1 inhibitor which promotes ferroptosis) on OSCC cells. This article assesses the anticancer effect and mechanism of PL as well as combined with CB-839. Methods: OSCC cells were treated with specified concentration of PL alone or with ferroptosis inhibitorFerrostatin-1 (Fer-1) and antioxidant N-Acetylcysteine (NAC) to assess their effects on biological characteristics such as cell proliferation, cell death and intracellular ferroptosis related pathways. Also, cells were treated with PL combined with CB-839 to evaluate the synergistic effect of CB-839 on PL's anticancer effects. Results:The results showed that the proliferation rate of PL-treated OSCC cells were decreased in a dose-and time-dependent manner. PL can induce OSCC cells apoptosis. Lipid peroxidation (LPO) and intracellular reactive oxygen species (ROS) were accumulated after PL treatment. We found some protein changes significantly such as the expression of DMT1 increased, and the expression of FTH1, SLC7A11 and GPX4 decreased. In addition, the anti-proliferation effect of PL can be reversed by Fer-1 and NAC and the level of LPO and ROS was decreased accordingly. Importantly, we found that PL and CB-839 in combination could decrease the cell viability and the LPO level synergistically, accompanied by a large consumption of glutathione (GSH). These evidences prove that PL can induce ferroptosis of OSCC cells, which can be enhanced by CB-839.Conclusions: Our study suggested that the nature product PL can induce the ferroptotic death of OSCC cells, which is further enhanced when combined with CB-839. The synergistic anticancer effect of these two may prove new strategy for OSCC treatment.

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Ferroptosis molecular inducers: A future direction for malignant tumor chemotherapy

Cited by 3 publications

References 98 publications

Recent progress in ferroptosis: inducers and inhibitors

Recent progress in ferroptosis: inducers and inhibitors

The crosslinks between ferroptosis and autophagy in asthma

Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity

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