Ferroptosis promotes sonodynamic therapy: a platinum(<scp>ii</scp>)–indocyanine sonosensitizer

Lai, Yidan; Lu, Nong; Ouyang, Ai; Zhang, Qianling; Zhang, Pingyu

doi:10.1039/d2sc02597c

Cited by 45 publications

(38 citation statements)

References 39 publications

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“…Recently, bipyridine-based cyclometalated Pt(II) complexes (13 and 14) (Figure 9) have been established as good sonosensitizer for cancer SDT. [64] Interestingly, the 1 O 2 generation ability of 8 was much higher on US exposure than on visible light (465 nm) exposure, as was evident from the rate constant for DPA oxidation (US: 0.00492 min À 1 vs. light: 0.00368 min À 1 ). As a result, the cytotoxicity of 14 against 4T1 cancer cells was higher under US (IC 50 ca.…”

mentioning

confidence: 89%

“…Compound 14 + US treatment significantly reduced the GSH level and GPX4 expression in 4T1 cells, indicating ferroptosis as the mode of cell death. [64] The metabolomics investigation indicated that 14 on US irradiation specifically altered the glutathione metabolism in 4T1 cells. Similar to complexes 2, 4-6, complex 14 also showed notable in-vivo anticancer activity on US irradiation.…”

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confidence: 98%

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Metal Complexes for Cancer Sonodynamic Therapy

et al. 2022

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Sonodynamic therapy (SDT) for cancer treatment is gaining attention owing to its non‐invasive property and ultrasound‘s (US) deep tissue penetration ability. In SDT, US activates the sonosensitizer at the target deep‐seated tumors to generate reactive oxygen species (ROS), which ultimately damage tumors. However, drawbacks such as insufficient ROS production, aggregation of sonosensitizer, off‐target side effects, etc., of the current organic/nanomaterial‐based sonosensitizers limit the effectiveness of cancer SDT. Very recently, metal complexes with tunable physiochemical properties (such as sonostability, HOMO to LUMO energy gap, ROS generation ability, aqueous solubility, emission, etc.) have been devised as effective sonosensitizers, which could overcome the limitations of organic/nanomaterial‐based sonosensitizers. This concept introduces all the reported metal‐based sonosensitizers and delineates the prospects of metal complexes in cancer sonodynamic therapy. This new concept of metal‐based sonosensitizer can deliver next‐generation cancer drugs.

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confidence: 89%

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confidence: 98%

Metal Complexes for Cancer Sonodynamic Therapy

et al. 2022

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“…Several recent studies have demonstrated the versatile therapeutic potential of nanomaterials that reveal induced-shear force as a sonodynamic effect causing LPO and ferroptosis. 41–44…”

Section: Ultrasoundmentioning

confidence: 99%

“…Several recent studies have demonstrated the versatile therapeutic potential of nanomaterials that reveal induced-shear force as a sonodynamic effect causing LPO and ferroptosis. [41][42][43][44] In 2021, Chen et al demonstrated synergistic tumor treatment via an SDT-based LPO mechanism to induce ferroptosis using ferumoxytol and a PpIX sonosensitizer (Fig. 4b).…”

Section: Sono-shear Force-mediated Cancer Therapymentioning

confidence: 99%

Mechanical stimuli-driven cancer therapeutics

Hong

Won

et al. 2023

Chem. Soc. Rev.

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“…Sonodynamic antimicrobial chemotherapy (SACT), on the basis of sonodynamic therapy (SDT), has been established and developed as a promising alternative for microbial inactivation. SACT is a combination of ultrasound and chemotherapeutic agents termed sonosensitizers to produce highly oxidative active reactive oxygen species and ultimately achieve treatment through the removal of bacterial biofilm infections (Yang et al, 2019;Lai et al, 2022). Compared with conventional treatment modalities, SACT has superior penetration ability and high target specificity, and can overcome resistance conferred by the local microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Synergistic antibacterial effects of ultrasound combined nanoparticles encapsulated with cellulase and levofloxacin on Bacillus Calmette-Guérin biofilms

Zhang

Yang

et al. 2023

Front. Microbiol.

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Tuberculosis is a chronic infectious disease, the treatment of which is challenging due to the formation of cellulose-containing biofilms by Mycobacterium tuberculosis (MTB). Herein, a composite nanoparticle loaded with cellulase (CL) and levofloxacin (LEV) (CL@LEV-NPs) was fabricated and then combined with ultrasound (US) irradiation to promote chemotherapy and sonodynamic antimicrobial effects on Bacillus Calmette-Guérin bacteria (BCG, a mode of MTB) biofilms. The CL@LEV-NPs containing polylactic acid-glycolic acid (PLGA) as the shell and CL and LEV as the core were encapsulated via double ultrasonic emulsification. The synthesized CL@LEV-NPs were uniformly round with an average diameter of 196.2 ± 2.89 nm, and the zeta potential of −14.96 ± 5.35 mV, displaying high biosafety and sonodynamic properties. Then, BCG biofilms were treated with ultrasound and CL@LEV-NPs separately or synergistically in vivo and in vitro. We found that ultrasound significantly promoted biofilms permeability and activated CL@LEV-NPs to generate large amounts of reactive oxygen species (ROS) in biofilms. The combined treatment of CL@LEV-NPs and US exhibited excellent anti-biofilm effects, as shown by significant reduction of biofilm biomass value and viability, destruction of biofilm architecture in vitro, elimination of biofilms from subcutaneous implant, and remission of local inflammation in vivo. Our study suggested that US combined with composite drug-loaded nanoparticles would be a novel non-invasive, safe, and effective treatment modality for the elimination of biofilm-associated infections caused by MTB.

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Ferroptosis promotes sonodynamic therapy: a platinum(ii)–indocyanine sonosensitizer

Abstract: Sonodynamic therapy (SDT) has unique advantages in deep tumour ablation due to its deep penetration depth, showing great preclinical and clinical potential. Herein, a platinum(II)-cyanine complex has been designed to...

Cited by 45 publications

References 39 publications

Metal Complexes for Cancer Sonodynamic Therapy

Metal Complexes for Cancer Sonodynamic Therapy

Mechanical stimuli-driven cancer therapeutics

Synergistic antibacterial effects of ultrasound combined nanoparticles encapsulated with cellulase and levofloxacin on Bacillus Calmette-Guérin biofilms

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