Fertility and human seminal plasma (HSP) hypersensitivity

Tan, Jessica; Bernstein, Jonathan A.

doi:10.1016/j.anai.2013.05.024

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…In women wanting to conceive, there are multiple cases reporting natural conception following subcutaneous and intravaginal desensitization (Table 4). 28,55 This, along with findings from Tan and Berstein demonstrating that the subjective success of immunotherapy does not affect ability to conceive, suggests that SPH has no direct impact on fertility 55 …”

Section: Resultsmentioning

confidence: 95%

“…Subcutaneous immunotherapy with PSA, the main allergen associated with SPH, and dog, due to suspected allergen cross‐reactivity, showed variable success 3,53 . Immunotherapy with whole seminal plasma was associated with adverse systemic reaction during the desensitization process but eventual symptom improvement 3,13,14,55 . Lavery et al.…”

Section: Resultsmentioning

confidence: 99%

“…28,55 This, along with findings from Tan and Berstein demonstrating that the subjective success of immunotherapy does not affect ability to conceive, suggests that SPH has no direct impact on fertility. 55 Many women with SPH utilized assisted reproductive technology to conceive (Table 4). The initial approach often involved artificial insemination with spermatozoa washed to remove seminal plasma.…”

Section: Managementmentioning

confidence: 93%

“…3,53 Immunotherapy with whole seminal plasma was associated with adverse systemic reaction during the desensitization process but eventual symptom improvement. 3,13,14,55 Lavery et al proposed the use of NSAIDs to alleviate residual symptoms following desensitization. 6 Alternatively, intravaginal desensitization with serial dilutions of seminal plasma showed 100% success in cases so long as desensitization was maintained with frequent unprotected intercourse or vaginal insertion of frozen semen if the partner is unavailable.…”

Section: Managementmentioning

confidence: 99%

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Seminal plasma hypersensitivity: A systematic review of clinical presentation, diagnostics, and management options

Schacher,

Dalloul,

Muneyyirci‐Delale

2024

American J Rep Immunol

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IntroductionSeminal plasma hypersensitivity (SPH) is a rare and often misdiagnosed condition characterized by local and/or systemic reactions to seminal plasma proteins following exposure to semen. We aimed to summarize key symptomatology, diagnostic features, and management options for SPH.MethodsThe databases PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Review were searched with key words “seminal plasma hypersensitivity” and “seminal fluid allergy” through September 2023. Exclusion criteria included non‐English articles, in vitro studies, publication before 1990, duplicates, and articles with no clinical relevance to SPH in women.ResultsThe search yielded 53 articles for review. Of these, 60.5% described systemic SPH and 39.5% described localized.ConclusionDiagnosis of SPH relies on a thorough patient history and confirmatory skin prick testing. The use of IgE assays is controversial and less accurate for cases of localized SPH. Knowledge of disease immunopathology, systemic versus localized symptom presentation, patient preference, and desire to conceive should guide management options. Artificial insemination has the potential for severe adverse reactions in systemic SPH so necessitates extra procedural precautions. SPH does not appear to impair fertility. Additional research on specific allergens implicated in SPH can aid in the development of more targeted immunotherapy approaches with improved safety and efficacy.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Managementmentioning

confidence: 93%

Section: Managementmentioning

confidence: 99%

See 2 more Smart Citations

Seminal plasma hypersensitivity: A systematic review of clinical presentation, diagnostics, and management options

Schacher,

Dalloul,

Muneyyirci‐Delale

2024

American J Rep Immunol

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Allergy and Sexual Behaviours: an Update

Caminati

Giorgis

Palterer

et al. 2017

Clinic Rev Allerg Immunol

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The exact prevalence of hypersensitivity reactions related to sexual behaviours is not known; however, they heavily impact on the quality of life and of sex life of affected patients. In fact, not only common respiratory and skin allergies, such as asthma, rhinitis, urticaria and atopic dermatitis, but also food and drug allergy have been found to negatively affect the quality of sex life. Allergic diseases impact on the sexual function in both physical and psychological ways, representing one of the main complaints of a considerable proportion of patients. Sexual behaviours may act as the triggers of allergic reactions or as the carriers of allergens. Food and drug allergens can be carried through human organic fluids, like saliva and semen. Latex in condoms and numerous substances in lubricants, spermicides, topical medications and cosmetics can cause allergic reactions or contact dermatitis. Sexual activity itself is also a potential trigger of symptoms in patients affected by respiratory allergies, like honeymoon asthma and rhinitis. In seminal plasma hypersensitivity, seminal fluid proteins are the culprit allergens. The present review aims at summarizing the state of the art about allergy and sexual behaviours. In clinical practice, the influence of common allergic diseases on the sexual quality of life should be taken carefully into account. Sexual behaviours need to be accounted in the differential diagnosis of hypersensitivity reactions, and awareness on those exposure routes should be raised between different specialists and general practitioners.

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