Fertility and infertility: Definition and epidemiology

Borght, Mélodie Vander; Wyns, Christine

doi:10.1016/j.clinbiochem.2018.03.012

Cited by 1,418 publications

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“…Infertile males were defined as having a history of infertility of at least 1-year duration despite regular unprotected intercourse with a fertile female partner. (Vander Borght & Wyns, 2018).…”

Section: Patientsmentioning

confidence: 99%

Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status

et al. 2020

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Several theories were proposed to explain the pathophysiology of varicocele‐related infertility seen in some patients. Our aim was to study the levels of angiotensin II in semen and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients in relation to their fertility status and to evaluate the influence of varicocelectomy on their levels in infertile varicocele patients. Thirty fertile and 30 infertile varicocele patients and 30 healthy controls were subjected to measurement of reproductive hormones, semen analysis, measurement of seminal angiotensin II and evaluation of angiotensin II type 2 receptor expression on spermatozoa. Infertile varicocele patients underwent varicocelectomy and were re‐evaluated for the same parameters after the operation. Sperm concentration, morphology, progressive motility, seminal angiotensin II and angiotensin II type 2 receptor expression were significantly lower in infertile varicocele patients compared with the other groups. Post‐operative values showed significant increase in the studied parameters compared with the pre‐operative values but not to other two groups. A significant positive correlation between angiotensin II type 2 receptor expression and progressive motility was detected in all studied groups. In conclusion, dysregulation of angiotensin II and angiotensin II type 2 receptor in varicocele patients may be involved in varicocele‐related infertility.

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Section: Patientsmentioning

confidence: 99%

Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status

et al. 2020

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confidence: 99%

“…A couple is defined as being affected by infertility if it is unable to conceive after 1 year of regular and unprotected sexual intercourse [Manvelyan et al, 2008;Vander Borght and Wyns, 2018]. Even though in ∼ 20% of affected individuals the reason for "the problem" remains enigmatic [Manvelyan et al, 2008], it is known that males are responsible for 20-30% of the infertility cases [Vander Borght and Wyns, 2018].…”

confidence: 99%

“…Even though in ∼ 20% of affected individuals the reason for "the problem" remains enigmatic [Manvelyan et al, 2008], it is known that males are responsible for 20-30% of the infertility cases [Vander Borght and Wyns, 2018]. Thus, especially in Western countries, postponing parenthood to the 3rd or even 4th decade of life, infertility is a major problem.Besides environmental factors and semen decline appearing with age, male infertility is mainly caused by testicular and post-testicular problems [Manvelyan et al, 2008;Vander Borght and Wyns, 2018]. Strikingly, otherwise phenotypically normal males may be infertile due Keywords aCGH · Banding cytogenetics · Impaired spermatogenesis · Molecular cytogenetics · Small supernumerary marker chromosomes Abstract Infertile male with small supernumerary marker chromosomes (sSMCs) were studied.…”

mentioning

confidence: 99%

“…There may be mutations in specific genes, like azoospermia factor ( AZF ) or cystic fibrosis transmembrane conductance regulator ( CFTR ) [Manvelyan et al, 2008;Wosnitzer et al, 2014;Röpke and Tüttelmann, 2017;Colaco and Modi, 2018;Vander Borght and Wyns, 2018]. Still, fertility may be impaired as well by (a) numerical chromosomal alterations, like (mosaic) trisomy or monosomy of (one of) the gonosomes [Mau-Holzmann, 2005;Manvelyan et al, 2007;Wosnitzer et al, 2014;Neto et al, 2016], (b) structural chromosomal abnormalities, like balanced rearrangements (translocations, insertions, inversions or even complex chromosomal rearrangements) [Liehr and Weise, 2007], or (c) a combination of numerical and structural chromosomal alterations, i.e., the presence of a small supernumerary marker chromosome (sSMC) [Manvelyan et al, 2008;Liehr, 2014;Armanet et al, 2015].…”

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confidence: 99%

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Impaired Spermatogenesis due to Small Supernumerary Marker Chromosomes: The Reason for Infertility Is Only Reliably Ascertainable by Cytogenetics

Liehr¹,

Al-Rikabi²

2018

Sex Dev

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Infertile male with small supernumerary marker chromosomes (sSMCs) were studied. Overall, 37 own patients and 166 cases from the literature were included. sSMCs of our own cases were characterized by multicolor-FISH probe sets. Available clinical data of the infertile males were also evaluated, and meta-analysis on suitability of molecular karyotyping for sSMC characterization was done. As a result, sSMCs can be optimally characterized by single-cell directed (molecular) cytogenetics. In infertile males, sSMCs derive predominantly from one of the acrocentric chromosomes, mainly chromosomes 15, 14, and 22. Interestingly, altered spermiograms were found in 62% of the males with an sSMC, while the remainder cases had infertility in connection with recurrent spontaneous abortions. Meta-analysis for detectability of sSMCs by aCGH revealed that 81-87% of the cases would have not been picked up by exclusive use of that approach. Thus, as impaired spermatogenesis is known to be indicative for gross chromosomal anomalies in infertile male patients, it can be concluded from this study that the presence of sSMCs also needs to be considered. However, sSMCs can only be reliably detected by standard karyotyping and not by modern high throughput approaches like aCGH and next-generation sequencing.

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Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

Liu,

Deng,

Chen

et al. 2024

JAMA Netw Open

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ImportanceNumerous studies have documented the association of self-rated health (SRH) with chronic diseases. However, few studies have investigated its association with semen quality.ObjectiveTo examine the association of SRH with semen quality among men undergoing assisted reproductive technology (ART) in China.Design, Setting, and ParticipantsThis cross-sectional study recruited male partners in couples undergoing ART treatment at the Center for Reproductive Medicine, Tongji Hospital, Wuhan, China. A total of 1262 men underwent 2 semen examinations and completed a questionnaire on SRH between December 2018 and January 2020. Data analysis was performed from November 20, 2022, to March 24, 2023.ExposureSRH, including overall physical and mental health, as well as reproductive-related physical and mental health specifically, were reported at baseline recruitment.Main Outcomes and MeasuresSperm concentration, sperm progressive motility, sperm motility, and sperm count as semen quality parameters.ResultsThe study included 1262 men with a mean (SD) age of 32.79 (5.25) years and body mass index of 24.37 (3.68). Men with poorer SRH had lower semen quality (eg, sperm concentration among poor vs very good overall physical health: percentage variation, −14.67%; 95% CI, −23.62% to −4.66%). Among 4 components of SRH, a greater reduction in semen quality was estimated for reproductive-related SRH compared with overall SRH, whereas the greatest reduction was observed for reproductive-related physical SRH. In comparison with men with very good reproductive-related physical SRH, men with poor reproductive-related physical SRH had differences of −24.78% (95% CI, −32.71% to −15.93%) and −25.61% (95% CI, −33.95% to −16.22%) in sperm count and concentration, respectively, and regression coefficients of −9.38 (95% CI, −12.01 to −6.76) and −9.24 (95% CI, −11.82 to −6.66) for sperm motility and sperm progressive motility, respectively.Conclusions and RelevanceIn this cross-sectional study of Chinese men, poorer SRH was associated with lower semen quality, and reproductive-related physical SRH was the most pronounced indicator. Our findings suggest that SRH, especially reproductive-related physical SRH, was a good indicator of semen quality, which should inform public and clinical regulatory decisions.

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Fertility and infertility: Definition and epidemiology

Cited by 1,418 publications

References 88 publications

Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status

Seminal levels of angiotensin II and angiotensin II type 2 receptor expression on spermatozoa in varicocele patients: Relation to fertility status

Impaired Spermatogenesis due to Small Supernumerary Marker Chromosomes: The Reason for Infertility Is Only Reliably Ascertainable by Cytogenetics

Self-Rated Health and Semen Quality in Men Undergoing Assisted Reproductive Technology

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