Fertility enhancing activity and toxicity profile of aqueous extract of<i>Chasmanthera dependens</i>roots in male rats

Quadri, A.L.; Yakubu, Musa Toyin

doi:10.1111/and.12775

Cited by 14 publications

(15 citation statements)

References 54 publications

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“…The pH of the intestinal uid collected was read using a pH cooperative paper (strip), ranged 5-9. This strip is capable of different colour change within this pH range which can be compared to a standard colour for a given pH value as supplied with the kit by the manufacturer [32]. The pH paper was dipped into the sample and the colour that developed was checked against known standards [32].…”

Section: Ph Of Intestinal Fluid Secretionmentioning

confidence: 99%

Ethanol Extract of Spondias mombin L. Leaves Exhibits Antidiarrhoeal Activity by Stimulation of Na+–K+ ATPase, Inhibition of Prostaglandins or Suppression of Nitric Oxide

Ogunro¹,

Ofeniforo

2021

Preprint

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This study was to justify the acclaimed antidiarrhoeal activity of ethanol extract of Spondias mombin leaves (EESML) and to suggest probable mechanism of action.EESML was screened for its secondary metabolites. The diarrhoeal models involved randomized Wistar rats in 5 groups of 6 animals each. Animals in groups A&B (negative and positive control) were treated with normal saline and loperamide respectively while those in groups C, D and E received 100, 200 and 400 mg/kg body weight of EESML respectively.EESML contained saponins, alkaloids, flavonoids, tannins, steroids, phenolics and glycosides. EESML lengthened the onset time of diarrhoea and as well caused reductions in the number, fresh weight and total number of wet feaces; and increase in the inhibition of defecations. EESML increased the intestinal activity of Na+–K+ ATPase; the concentrations of intestinal Na+, K+, Cl-, total protein and glucose but decreased the concentration of nitric oxide of the diarrhoeal rats. The intestinal fluid concentrations of Na+, K+, Cl- were dose dependently increased by EESML. EESML also increased the length of the small intestine.EESML possess antidiarrhoeal activity owing to the secondary metabolites, ability to enhance Na+–K+ATPase activity and electrolytes as well as suppression of nitric oxide.

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Section: Ph Of Intestinal Fluid Secretionmentioning

confidence: 99%

Ethanol Extract of Spondias mombin L. Leaves Exhibits Antidiarrhoeal Activity by Stimulation of Na+–K+ ATPase, Inhibition of Prostaglandins or Suppression of Nitric Oxide

Ogunro¹,

Ofeniforo

2021

Preprint

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“…Ten μL of the semen suspension was collected and inserted into the haemocytometer. It was immediately examined at x40 magnification under the microscope (Olympus Co., Tokyo, Japan) (Quadri and Yakubu, 2017).…”

Section: Sperm Count Analysismentioning

confidence: 99%

“…Progressive and non-progressive movement of sperm cells under the microscope describes motile sperm cells. It was calculated according to the number of motile sperm cells divided by the total number of sperm cells counted (Quadri and Yakubu, 2017).…”

Section: Sperm Motility Testmentioning

confidence: 99%

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Evaluation of sperm quality in male rats treated with Sauropus androgynus (L.) merr. leaf fractions

2020

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Sauropus androgynus (L.) Merr. or katuk is one of the medicinal plants broadly used in Indonesia as it has active compounds that can, among others, stimulate reproductive hormones. This study was aimed to determine which active fraction of S. androgynus leaves that have the potential to improve the sperm quality of male rats based on three parameters, namely sperm count, viability, and motility. It employed fractionation using the liquid-liquid extraction with n-hexane, ethyl acetate, and water solvents to obtain the fractions. Twenty-four mature Sprague-Dawley male rats were divided into four equal groups: the normal group (untreated group) received 0.5% Na-CMC suspense, and the three fraction groups were given the n-hexane, ethyl acetate, and water fraction p.o., respectively, at the dose of 11.85 mg.Kg-1 BW daily for seven days. Sperm count, viability, and motility were measured on day 8 (after treatment) from the sperm samples collected at the cauda epididymis of the sacrificed test rats. The results showed that compared with the normal group, the n-hexane and ethyl acetate fractions significantly increased the three parameters (p<0.05). Therefore, the S. androgynus leaf fractions have the potential as a natural material that can increase the fertility of male rats.

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“…In Nigeria, the stem of C dependens together with other plants is used in the treatment of convulsions and epilepsiy, while in congo, its root sap is applied on wounds to stop bleeding (Mosango, 2008;Monon et al, 2013;Wahab, 2015). C. dependens has been shown from previous studies, to possess analgesic and anti-inflammatory (Onabanjo et al, 1991;Kola-Mustapha, et al, 2020), antiulcerogenic (Tijani et al, 2018), fertilityenhancing (Quadri, & Yakubu, 2017), hepatocurative (Ogbozor and Anosike, 2020), and nephroprotective (Abiola et al, 2020) effects.…”

Section: Introductionmentioning

confidence: 98%

Evaluation of Antioxidant Properties of Choloroform Extract of Chasmanthera dependens Roots

Madueke¹,

Nwanelo²,

Tabansi³

et al. 2020

The 1st International E-Conference on Antioxidants in Health and Disease

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Chasmanthera dependens is a medicinal plant with wide application in African traditional medicine for the management of several pathologies. We report the antioxidant properties of the chloroform extract of C. Dependens root (CECDR) as to auspiciously provide scientific information that could explain some of the reported roles of the plant in human diseases. In vitro studies assayed for 1,1-diphenyl2-picrylhydrazyl (DPPH) scavenging, hydrogen peroxide scavenging, ferric reducing antioxidant power (FRAP), and total antioxidant capacity (TAC). DPPH radical scavenging activity was concentration dependent with an EC50 of 647.67 μg/mL. CECDR showed a positive hydrogen peroxide scavenging with EC50 of 57.78 ± 2.93 μg/mL relative to ascorbic acid standard (EC50: 90.06 μg/mL). The ferric reducing antioxidant power of CECDR at 15.6 μg/mL was 21.18 ± 0.15 µg gallic acid equivalents (GAE) while that of 1000 μg/mL was 0.03 ± 0.00 µg GAE. CECDR at a concentration 15.6 μg/mL showed a TAC of 15.22 ± 7.81 µg ascorbic acid equivalents (AAE) while that of 1000 μg/mL was 0.03 ± 0.00 µg AAE. In vivo analysis of CCl4-induced Wistar rats showed a significant increase (p < 0.05) in the concentrations of superoxide dismutase, catalase, and glutathione peroxidase in the treated groups relative to the untreated control. In conclusion the observed antioxidant properties of CECDR could be attributed to its rich phytochemical repertoire.

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Fertility enhancing activity and toxicity profile of aqueous extract ofChasmanthera dependensroots in male rats

Cited by 14 publications

References 54 publications

Ethanol Extract of Spondias mombin L. Leaves Exhibits Antidiarrhoeal Activity by Stimulation of Na+–K+ ATPase, Inhibition of Prostaglandins or Suppression of Nitric Oxide

Ethanol Extract of Spondias mombin L. Leaves Exhibits Antidiarrhoeal Activity by Stimulation of Na+–K+ ATPase, Inhibition of Prostaglandins or Suppression of Nitric Oxide

Evaluation of sperm quality in male rats treated with Sauropus androgynus (L.) merr. leaf fractions

Evaluation of Antioxidant Properties of Choloroform Extract of Chasmanthera dependens Roots

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